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BAMIPINE

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BAMIPINE Basic information

Product Name:
BAMIPINE
Synonyms:
  • Taumidrin
  • BAMIPINE
  • 4-(N-Benzylanilino)-1-methylpiperidine
  • 4-(n-benzyl-n-phenylamino)-1-methyl-piperidin
  • 4-(N-Benzyl-N-phenylamino)-1-methylpiperidine
  • 4-Piperidinamine, 1-methyl-N-phenyl-N-(phenylmethyl)-
  • N-Benzyl-1-methyl-N-phenyl-4-piperidinamine
  • N-Phenyl-N-benzyl-4-amino-1-methyl-piperidine
CAS:
4945-47-5
MF:
C19H24N2
MW:
280.41
EINECS:
225-587-2
Mol File:
4945-47-5.mol
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BAMIPINE Chemical Properties

Melting point:
115°
Boiling point:
413.12°C (rough estimate)
Density 
0.9608 (rough estimate)
refractive index 
1.8676 (estimate)
pka
pKa 3.34±0.04 (H2O t unde?ned I=0.30(NaCl)) (Uncertain);8.04±0.11(H2O t unde?ned I=0.30(NaCl)) (Uncertain)
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BAMIPINE Usage And Synthesis

Originator

Bamipine,Pharm Chemical

Uses

Bamipine is an antihistamine that has anticholinergic properties. It is also a reagent for dopamine D3 receptor ligands based on scaffolds of biogenic amine GPCR (G protein-coupled receptor) ligands.

Definition

ChEBI: Bamipine is an aromatic amine.

Manufacturing Process

80 g of 1-methyl-piperidone-4 and 70 g of aniline are boiled, using a water separator in 350 ml of toluene to which several drops of glacial acetic acid have been added, until the theoretical quantity of water (12.7 ml) has separated out. The toluene is then distilled off and the remains are fractionated at reduced pressure. At a boiling point of 156°C/13 mm of Hg pressure, 118 g of a weakly yellow colored oil of the anil of 1-methyl-1- piperidone-4 are obtained.
100 g of the above described anil of 1-methyl-1-piperidone-4 are boiled for 8 hours, using a reflux condenser, with 30 g of activated borings of aluminum in 300 ml of methanol diluted with 60 ml of water. The liquid phase is then separated from the solid phase, the solvent is evaporated and the residuum is fractionated at reduced pressure, 95 g of a colorless oil being obtained boiling at 163-165°C at 15 mm of Hg pressure. The oil solidifies at once to a mass of crystals of 4-N-phenylaimno-1-methylpiperidine. After having been recrystallized from dibutyl ether the base melts at 87°C, its dihydrochloride has the melting point of 246°C.
95 g of 4-N-phenylamino-1-methylpiperidine are boiled together with 22 g of pulverized sodium amide in 300 ml of benzene, using a reflux condenser, while nitrogen is passed through the reaction mixture, until the evolution of ammonia has ceased. 64 g of benzyl chloride are then gradually added drop by drop to the boiling reaction product and boiling is continued for several hours. After having been cooled the solution is shaken with water and subsequently dried with potassium carbonate. The solvent having been evaporated the remaining base of 4-(N-phenyl-N-benzyl)-amino-1- methylpiperidine solidifies with the formation of crystals, the yield amounting to 123 g. The base is recrystallized from dibutyl ether and has a melting point of 115°C; its dihydrochloride melts at 189°C.

Therapeutic Function

Antihistaminic, Antiallergic

BAMIPINESupplier

Energy Chemical
Tel
021-58432009 400-005-6266
Email
marketing@energy-chemical.com
Hubei Nordina Biotechnology Co., Ltd.
Tel
19371278702
Email
nuodinashengwu@163.com
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
17691182729 18161915376
Email
1046@dideu.com
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
023-19371278 19371278702
Email
n13164103386@163.com
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
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BAMIPINE(4945-47-5)Related Product Information