4-CHLORO-6-METHYLQUINAZOLINE Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

4-CHLORO-6-METHYLQUINAZOLINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 4-chloro-6-methylquinazoline from 6-methyl-4-hydroxyquinazoline was as follows: intermediate 10-b (2.1 g, 13.11 mmol) was dissolved in chloroform (30 ml). Oxalyl chloride (1.97 g, 23.26 mmol) and N,N-dimethylformamide (0.1 ml) were subsequently added. The reaction mixture was heated to 100°C and maintained at this temperature for 3 hours. Upon completion of the reaction, the solvent was removed by evaporation to afford intermediate 10 (1.5 g, 58% yield). Mass spectrometry analysis showed m/z = 179 ([M + H]+).

References

[1] Patent: WO2016/91791, 2016, A1. Location in patent: Page/Page column 20; 21
[2] Patent: WO2016/91774, 2016, A1. Location in patent: Page/Page column 23; 24
[3] Archiv der Pharmazie, 2013, vol. 346, # 1, p. 44 - 52

4-CHLORO-6-METHYLQUINAZOLINE(58421-79-7)Related Product Information

• 4-CHLORO-2-(2-FLUORO-PHENYL)-6-METHYL-QUINAZOLINE
• 4-CHLORO-2-TRIFLUOROMETHYL-QUINAZOLINE-6-CARBOXYLIC ACID ETHYL ESTER
• 4-CHLORO-6-METHYL-2-PHENYL-QUINAZOLINE
• 2-(4-BROMO-PHENYL)-4-CHLORO-6-METHYL-QUINAZOLINE
• ethyl 4-chloroquinazoline-6-carboxylate
• 2,4-DICHLORO-6-METHYLQUINAZOLINE
• 4-CHLORO-6-METHYLQUINAZOLINE
• 4-CHLORO-6,8-DIMETHYLQUINAZOLINE
• 4-CHLORO-2-(4-CHLORO-PHENYL)-6-METHYL-QUINAZOLINE
• 2,4-DICHLORO-6-(TRIFLUOROMETHYL)-QUINAZOLINE
• 4-CHLORO-2-(4-METHOXY-PHENYL)-6-METHYL-QUINAZOLINE
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• 4-chloro-6-(trifluoromethyl)quinazoline
• 4-CHLORO-2-(4-FLUORO-PHENYL)-6-METHYL-QUINAZOLINE
• 6-(BROMOMETHYL)-4-CHLOROQUINAZOLINE