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4'-CHLOROACETANILIDE

Basic information Safety Supplier Related

4'-CHLOROACETANILIDE Basic information

Product Name:
4'-CHLOROACETANILIDE
Synonyms:
  • ACETIC ACID 4-CHLOROANILIDE
  • ACETAMINOPHEN IMPURITY J
  • ACETAMINOPHENE IMP J
  • 4'-CHLOROACETANILIDE
  • 4-CHLOROACETANILIDE
  • 4-CHLORACETANILIDE
  • LABOTEST-BB LT00792311
  • P-CHLOROACETANILIDE
CAS:
539-03-7
MF:
C8H8ClNO
MW:
169.61
EINECS:
208-707-8
Product Categories:
  • Amines
  • Aromatics
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Anilines, Amides & Amines
  • Chlorine Compounds
Mol File:
539-03-7.mol
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4'-CHLOROACETANILIDE Chemical Properties

Melting point:
176-178 °C(lit.)
Boiling point:
333 °C
Density 
1,385 g/cm3
refractive index 
1.5670 (estimate)
Flash point:
333°C
storage temp. 
2-8°C
solubility 
dioxane: 50 mg/mL hot, clear
pka
14.25±0.70(Predicted)
form 
Crystalline Powder
color 
White or grayish-beige
Water Solubility 
Insoluble in water.
Merck 
14,2111
BRN 
509638
CAS DataBase Reference
539-03-7(CAS DataBase Reference)
EPA Substance Registry System
4-Chloroacetanilide (539-03-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AE1001000
TSCA 
Yes
HS Code 
29242990
Hazardous Substances Data
539-03-7(Hazardous Substances Data)

MSDS

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4'-CHLOROACETANILIDE Usage And Synthesis

Chemical Properties

white or greyish-beige crystalline powder

Uses

4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.

Definition

ChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.

Synthesis Reference(s)

Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4

General Description

4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.

Purification Methods

Crystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]

4'-CHLOROACETANILIDESupplier

Shandong RuiYue Biotechnology Co., Ltd. Gold
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