3,5-Diethyl-1,2-dihydro-1-phenyl-2-propylpyridine Chemical Properties

Boiling point:

125℃/0.5mm

Density 

0.97

vapor pressure 

0.003Pa at 25℃

Flash point:

>148 °C

refractive index 

1.5675

storage temp. 

2-8°C

pka

0.85±0.70(Predicted)

Water Solubility 

53.23μg/L at 25℃

InChI

InChI=1S/C18H25N/c1-4-10-18-16(6-3)13-15(5-2)14-19(18)17-11-8-7-9-12-17/h7-9,11-14,18H,4-6,10H2,1-3H3

InChIKey

IAAASXBHFUJLHW-UHFFFAOYSA-N

SMILES

C1(CCC)N(C2=CC=CC=C2)C=C(CC)C=C1CC

LogP

6.5 at 20℃

EPA Substance Registry System

3,5-Diethyl-1,2-dihydro-1-phenyl-2-propylpyridine (34562-31-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22-36/38

Safety Statements 

26

TSCA 

Yes

3,5-Diethyl-1,2-dihydro-1-phenyl-2-propylpyridine Usage And Synthesis

Uses

3,5-diethyl-1,2-dihydro-1-phenyl-2-propylpyridine (DHP) is the main active ingredient resulting from the condensation reaction of butyraldehyde and aniline. It is a useful research chemical.

Preparation

3,5-diethyl-1,2-dihydro-1-phenyl-2-propylpyridine (DHP) was prepared using methods shown below. A 1000 mL four neck flask was equipped with a mechanical stirrer, a reflux condenser, a thermometer, and an addition funnel. An ice-water bath was used to cool the flask as needed. The flask was charged with 86 g de-ionized water, 9.8 g (0.16 mole) acetic acid, and 216 g (3.0 mol) butyraldehyde. With cooling and stirring, 60 g (0.64 mole) aniline was added over a 35-minute period while maintaining the reaction temperature at 20℃. The reaction mixture was stirred for one hour at less than 25℃. The reaction mixture was then heated to 750C and held for two hours. Finally, the reaction mixture was heated to reflux (~90°C) and was held for five hours. The reaction mixture was cooled and the layers were separated. The top, organic layer was distilled through a 14" packed column under reduced pressure. The fraction taken at a head temperature of 140-1430C and 5 mm Hg pressure weighed 104 grams and was analyzed to contain 73% DHP for an overall yield of 46%.

3,5-Diethyl-1,2-dihydro-1-phenyl-2-propylpyridine(34562-31-7)Related Product Information

• ETHYL METHYL ETHER
• 3,5-Diethyl-1,2-dihydro-1-phenyl-2-propylpyridine