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ALPHA-BOSWELLIC ACID

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ALPHA-BOSWELLIC ACID Basic information

Product Name:
ALPHA-BOSWELLIC ACID
Synonyms:
  • A-BOSWELLIC ACID
  • A-ALPHA-BOSWELLIC ACID
  • ALPHA-BOSWELLIC ACID
  • BOSWELLIC ACID, A-
  • BOSWELLIC ACID, a-(SH)
  • 3alpha-Hydroxy-12-oleanen-24-oic acid
  • (3α,4β)-3-Hydroxyolean-12-en-23-oic Acid
  • 3α-hydroxyolean-12-en-24-oic Acid
CAS:
471-66-9
MF:
C30H48O3
MW:
456.7
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Miscellaneous Natural Products
Mol File:
471-66-9.mol
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ALPHA-BOSWELLIC ACID Chemical Properties

Melting point:
289℃
Boiling point:
552.7±50.0 °C(Predicted)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.50±0.70(Predicted)
color 
White to Off-White
Water Solubility 
practically insoluble in water
BRN 
3074442
LogP
9.430 (est)
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Safety Information

WGK Germany 
3
HS Code 
29181990
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ALPHA-BOSWELLIC ACID Usage And Synthesis

Chemical Properties

It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from frankincense.

Uses

ALPHA-BOSWELLIC ACID is the principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.

in vivo

alpha-Boswellic acid (3 or 10 mg/kg, intraperitoneal injection) decreases epidermal thickening, mast cell count and dermal infiltration in BALB/c mice induced by 2, 4-dinitrochlorobenzene[1].
alpha-Boswellic acid (200 mg/kg, gavage) has a protective effect on ethanol-induced gastric injury in rats[2].

Animal Model:2,4-Dinitrochlorobenzene-Induced Atopic-like Dermatitis in BALB/c Mice[1]
Dosage:3 or 10 mg/kg
Administration:i.p.
Result:Reduced the severity of the AD-like symptoms.
Attenuated the increase in ear thickness and decreased cutaneous TEWL in DNCB-treated mice.
Animal Model:Ethanol-induced gastric injury in rats[2]
Dosage:200 mg/kg
Administration:i.g.
Result:Reduced injuries associated with the administration of ethanol, gastric juice acidity and the formation of MDA and increased CAT activity and SOD activity and the level of NO and PGE-2 in a dose-depended manner.
Increased the expression of both Nrf2 and HO-1.

target

NO | PGE | Nrf2 | HO-1 | ROS

ALPHA-BOSWELLIC ACIDSupplier

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