Basic information Identification Test Content Analysis Toxicity Grade Acute Toxicity Use Quantity Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and Derivatives >  Methionine derivatives >  N-Acetyl-L-methionine

N-Acetyl-L-methionine

Basic information Identification Test Content Analysis Toxicity Grade Acute Toxicity Use Quantity Safety Supplier Related

N-Acetyl-L-methionine Basic information

Product Name:
N-Acetyl-L-methionine
Synonyms:
  • N-ACETYL-L-METHIONINE:AC-MET-OH
  • (2S)-N-ACETYL-L-METHIONINE
  • N-Acetylmethionine
  • Ac-L-Met-OH
  • N-alpha-Actetyl-L-methionine
  • N-Acetyl-L-methionine >99%
  • N-Acetyl-L-methionine (NAM), 98.5%
  • N-ACETYL-L-MET
CAS:
65-82-7
MF:
C7H13NO3S
MW:
191.25
EINECS:
200-617-7
Product Categories:
  • Amino Acids
  • Amino Acid Derivatives
  • Methionine [Met, M]
  • Ac-Amino Acids
  • Amino Acids (N-Protected)
  • amino
  • Biochemistry
  • Pharmaceutical Intermediates
  • Amino Acid Derivatives
  • Methionine
  • Peptide Synthesis
  • 99%min
Mol File:
65-82-7.mol
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N-Acetyl-L-methionine Chemical Properties

Melting point:
103-106 °C(lit.)
alpha 
-20 º (c=4 H2O)
Boiling point:
235 °C(Press: 12 Torr)
Density 
1.2684 (rough estimate)
refractive index 
-21 ° (C=1, H2O)
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: soluble100mg/mL, clear, colorless
pka
3.50±0.10(Predicted)
form 
Solid
color 
White to Off-White
optical activity
[α]20/D -21.0±1.0°, c = 1% in H2O
Merck 
14,96
BRN 
1725552
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
XUYPXLNMDZIRQH-LURJTMIESA-N
LogP
-0.885 (est)
CAS DataBase Reference
65-82-7(CAS DataBase Reference)
NIST Chemistry Reference
N-acetylmethionine(65-82-7)
EPA Substance Registry System
L-Methionine, N-acetyl- (65-82-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
RTECS 
PD0480000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29309070

MSDS

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N-Acetyl-L-methionine Usage And Synthesis

Identification Test

Take a sample of 250mg, get it dissolved it in 2.5ml isopropyl alcohol and get it diluted with water to 25ml. Take this liquid of 10ml and get it diluted with water to 100m1. Then take the liquid of 0.5,30 and 50μ1 after two dilutions. Drop it at the place with a distance of 2cm from the bottom edge of the thin-layer chromatographic plate. The plate is coated with silica gel (Namely, 20cm * 20cm Brinkman silica gel of 60.250nm, or the equivalent). In a sealed and balanced thin-layered chromatography expansion tank, The chromatography was splayed out by 10cm, and the developer was composed of n-butanol and the mixture of acetic acid and water in the proportion 75:20=20.

Dry the plate overnight. Then spray the chromatography plate with a new iodoplatinate solution mixed with 10 percent chloroplatinic acid of 3ml, water of 97ml and 6 percent potassium iodide solution of 100ml. The sample shall be formed - a separate color spot with a Rf value of 0.67~0.1

Content Analysis

Weigh accurately about 250mg sample and put it in a flask with glass stopper. Add 100ml water, 5g dipotassium hydrogen phosphate, 2g potassium dihydrogen phosphate and 2g potassium iodide. Get it fully mixed and dissolved, plus 0. 1mol/L iodine solution of 50.0m1. Then stopper it and blend it. Leave it stand for 30 minutes and titrate excess iodine with 0.1mol / L sodium thiosulfate. Meanwhile conduct blank titration experiment. Iodine solution per Ml 0.1mol/L equals to this product (C7H13NO3S) 9.563mg.

Toxicity Grade

Safe for food(FDA,§172.372,2000).

Acute Toxicity

Vein - mouse LD50: 435 mg / kg

Use Quantity

Account for 3.1% of the total protein content in food (Calculated by free L- methionine).
It shall not be used for infant food and food containing adding nitrite / nitrate (FDA, 172.3722000).

Chemical Properties

white crystals

Uses

N-Acetyl-L-methionine (CAS# 65-82-7) has been useful in the study of metabolic phenotypes of standard and cold-?stored platelets.

Definition

ChEBI: An L-methionine derivative that is L-methionine in which one of the amine hydrogens is substituted by an acetyl group.

Safety Profile

Poison by intravenous route. When heated to decomposition emits toxic fumes of NOX,.

Purification Methods

Crystallise N-acetyl-L-methionine from Me2CO, H2O or EtOAc. Dry it in a vacuum over P2O5. Its solubility at 25o in H2O is 30.7%, and in Me2CO it is 29.5%. [Mitzi & Schueter Biochim Biophys Acta 27 168 1958, Birnbaum et al. J Biol Chem 194 455 1952, Beilstein 4 IV 3206.]

N-Acetyl-L-methionine Preparation Products And Raw materials

Raw materials

N-Acetyl-L-methionineSupplier

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