1,3-DIAZA-SPIRO[4.4]NONANE-2,4-DIONE Chemical Properties

Melting point:

204-205℃

Density 

1.31

storage temp. 

2-8°C

solubility 

DMSO: 2 mg/mL, clear

form 

powder

pka

10.46±0.20(Predicted)

color 

white to beige

Appearance

White to off-white Solid

InChI

InChI=1S/C7H10N2O2/c10-5-7(3-1-2-4-7)9-6(11)8-5/h1-4H2,(H2,8,9,10,11)

InChIKey

JTTFXYHJDZZDQK-UHFFFAOYSA-N

SMILES

N1C2(CCCC2)C(=O)NC1=O

Safety Information

HS Code 

2933998090

1,3-DIAZA-SPIRO[4.4]NONANE-2,4-DIONE Usage And Synthesis

Uses

Non-toxic spiro-hydantoin, reverses plant vernalization epigenetically by reducing H3K27me3 at FLC, enabling heat-free control over flowering time.
DVR06, identified in Arabidopsis thaliana, induces devernalization, reversing the vernalized state at ambient temperatures. Its core function is reactivating the floral repressor FLC within the nucleus, notably in vascular and meristematic tissues. Mechanistically, DVR06 reduces repressive H3K27me3 histone methylation at the FLC locus and other genomic sites, while leaving active H3K4me3 marks unchanged. This epigenetic modulation delays flowering time and enhances vegetative growth. Possessing low toxicity and key hydantoin/spiro pharmacophores, DVR06 serves as a valuable chemical probe for epigenetic memory and holds potential for agricultural control over plant life cycles.

1,3-DIAZA-SPIRO[4.4]NONANE-2,4-DIONE(699-51-4)Related Product Information

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