Tangeretin Chemical Properties

Melting point:

153.0 to 157.0 °C

Boiling point:

565.3±50.0 °C(Predicted)

Density 

1.244±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO : 25 mg/mL (67.14 mM; Need ultrasonic)

form 

Solid

color 

White to Almost white

BRN 

351695

LogP

1.788 (est)

CAS DataBase Reference

481-53-8(CAS DataBase Reference)

NIST Chemistry Reference

Tangeretin(481-53-8)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

25-36/37/38

Safety Statements 

45-36-26

RIDADR 

UN 2811

WGK Germany 

3

RTECS 

DJ3102725

HS Code 

29329990

Toxicity

rat,LD50,intraperitoneal,> 1gm/kg (1000mg/kg),Advances in Teratology. Vol. 3, Pg. 181, 1968.

Tangeretin Usage And Synthesis

Chemical Properties

Tangeretin is a yellow crystal that is volatile, difficult to dissolve in water, and easily soluble in organic solvents such as ethanol and ether. It is the active ingredient in tangerine peel. It has a good effect in treating animal mites.

Uses

Tangeretin has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae. It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells.

Definition

ChEBI: Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite.

General Description

Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata.

Biological Activity

Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines.

Tangeretin(481-53-8)Related Product Information

• 4-Methoxyphenylacetic acid
• p-Anisaldehyde
• (Trifluoromethoxy)benzene
• Anisole
• 4-Methoxyphenylacetone
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• p-Anisidine
• 4-Methoxybenzylchloride
• Rotundine
• Quercetin dihydrate
• Sophoricoside
• 2,3,4,5-Tetramethoxytoluene
• Eugenol
• Nobiletin
• cirsimaritin
• 2-ETHOXY-3-METHOXYBENZALDEHYDE
• 5,6,7-TRIMETHOXYFLAVONE
• Acetosyringone