Cromolyn Disodium Salt Chemical Properties

Melting point:

241-2420C (dec)

storage temp. 

2-8°C

solubility 

Soluble in water, practically insoluble in ethanol (96 per cent).

form 

Solid

color 

White to Off-White

Water Solubility 

Soluble in water to 100mg/ml

Merck 

14,2590

Stability:

Hygroscopyc

InChIKey

VLARUOGDXDTHEH-UHFFFAOYSA-L

CAS DataBase Reference

15826-37-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3249

WGK Germany 

2

RTECS 

DJ2380000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29329990

Toxicity

LD50 in mice, rats (mg/kg): >8000 orally (Cox)

MSDS

• Language:English Provider:SigmaAldrich

Cromolyn Disodium Salt Usage And Synthesis

Description

Sodium cromoglycate is the sodium salt and common market from of cromoglicic acid, which is a synthetic compound, and as a mast cell stabilizer. It is capable of inhibiting the antigen-induced bronchospasms, and thus being used to treat the asthma and allergic rhinitis. It can also be applied as an ophthalmic solution for the treatment of conjunctivitis and systemic mastocytosis and ulcerative colitis. It is capable of inhibiting the degranulation of mast cells, further preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), the mediators of type I allergic reaction. It is also capable of inhibiting the release of inflammatory leukotrienes and inhibiting calcium influx.

References

https://www.drugbank.ca/drugs/DB01003
https://en.wikipedia.org/wiki/Cromoglicic_acid

Description

Disodium cromoglycateis a relatively nontoxic agent used for the long-term prevention of many types of asthma. It has no bronchodilator properties and is used in the prophylaxis of asthma. It does not play a role in the treatment of acute asthmatic attacks including severe asthma.

Chemical Properties

White Crystalline Powder

Originator

Intal,Fisons,UK,1969

Uses

Chromone complex which blocks mast cell degranulation

Uses

antiasthmatic, antiallergy

Uses

Anti Asthamatic

Definition

ChEBI: An organic sodium salt that is the disodium salt of cromoglycic acid.

Indications

Cromolyn sodium (Intal) is chemically related drugs called chromones that is used for the prophylaxis of mild or moderate asthma. It is administered by inhalation and has very good safety profiles, making them particularly useful in treating children.

Manufacturing Process

To a solution of 970 parts of 2,6-dihydroxyacetophenone and 325 parts of epichlorohydrin in 1,500 parts of hot isopropanol was added, with stirring under reflux, a solution of 233 parts of 85% KOH in 2,500 parts of isopropanol and sufficient water (ca 100 parts) to dissolve the solid. The mixture was heated, with stirring, under reflux for 48 hours. Half the solvent was then distilled off and 5,000 parts of water were added. The mixture was cooled and the solid filtered off and washed with isopropanol and ether. It was then recrystallized from 12,500 parts of isopropanol to obtain a first crop of 380 parts and a second crop, after concentration, of 300 parts of 1,3-bis(2- acetyl-3-hydroxyphenoxy)-2hydroxypropane.
4.6 parts of 1,3-bis(2-acetyl-3-hydroxyphenoxy)-2-hydroxypropane were reacted with diethyl oxalate and the product cyclized to obtain 4.4 parts of pure diethyl ester of 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane as pale yellow crystals melting between 180° and 182°C from a mixture of benzene and petrol, 4 parts of the diethyl ester of 1,3-bis(2-carboxychromon5-yloxy)-2-hydroxypropane were saponified with sodium hydroxide to obtain 3.2 parts of the disodium salt tetrahydrate as colorless crystals from aqueous alcohol.

Therapeutic Function

Bronchodilator

General Description

Cromolyn sodium, disodium 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane (Intal), isa hygroscopic, white, hydrated crystalline powder that is solublein water (1:10). It is tasteless at first but leaves a veryslightly bitter aftertaste. The pK of cromolyn is 2. It is availableas a solution for a nebulizer, an aerosol spray, a nasal solution,an ophthalmic solution, and an oral concentrate.
Nebulized and aerosol cromolyn has been used for prophylacticmanagement of bronchial asthma and prevention ofexercise-induced bronchospasm. Cromolyn nasal solution isused for the prevention and treatment of allergic rhinitis, andoral concentrate is used to treat the histaminic symptomsof mastocytosis (diarrhea, flushing, headaches, vomiting, urticaria,abdominal pain, nausea, and itching). Topical cromolyn(eye drops) is used to treat allergic conjunctivitis andkeratitis. In the treatment of asthma, cromolyn efficacy is manifestedby decreased severity of clinical symptoms, or need for concomitant therapy, or both. Long-term use is justified if thedrug significantly reduces the severity of asthma symptoms;permits a significant reduction in, or elimination of, steroiddosage; or improves management of those who have intolerableside effects to sympathomimetic agents or methylxanthines.For cromolyn to be effective, it must be administered atleast 30 minutes prior to antigen challenge and administered atregular intervals (see dosing information that follows). Wheninhaled, the powder does produce irritation in some patients.Also, overuse of cromolyn can result in tolerance.

Biochem/physiol Actions

Cromolyn blocks the release of histamine and other pro-inflammatory mediators from mast cells.

Mechanism of action

The precise mechanism or mechanisms whereby cromolyn sodium and nedocromil sodium exert their antiasthmatic activities is unknown. Early work suggested that these agents act by “stabilizing” mast cells, preventing mediator release. However, several other compounds exhibit greater potency for stabilization of mast cells yet possess no clinical efficacy in asthma.This suggests that the therapeutic activity of cromolyn sodium and nedocromil sodium in asthma is related to one or more other pharmacological mechanisms. Postulates include inhibitory effects on irritant receptors, nerves, plasma exudation, and inflammatory cells in general.

Pharmacokinetics

Cromolyn sodium is a bischromone that contains the fundamental benzopyrone moiety of khellin. The two chromone rings are necessary for activity and must be coplanar, with a linking chain of no longer than six carbons. If one changes the linking chain to positions 8 and 8′, coplanarity cannot be maintained, and the compound loses all activity. Cromolyn sodium is poorly absorbed from the lungs (~8%), insignificantly from the eye (~0.07%), and by approximately 1% from the GI tract. What little that finds its way into systemic circulation is eliminated intact in the urine and the bile. For the treatment of asthma, cromolyn sodium is available as a solution for both intranasal and inhalation administration. There also is an oral concentrate (100 mg/5 mL), which is administered as a 200-mg dose given four times a day.

Clinical Use

Cromolyn sodium is used almost exclusively for the prophylactic treatment of mild to moderate asthma and should not be used for the control of acute bronchospasm. This agent is effective in about 60 to 70% of children and adolescents with asthma. Unfortunately, there is no reliable means to predict which patients will respond.It is less effective in older patients and in patients with severe asthma. It may take up to 4 to 6 weeks of treatment for cromolyn sodium to be effective in chronic asthma, but it is effective after a single dose in exercise-induced asthma. With respect to clinical efficacy, cromolyn sodium and nedocromil sodium do not differ in a substantial way.

Side effects

Cromolyn sodium is the least toxic of available therapies for asthma. Adverse reactions are rare and generally minor. Those occurring in fewer than 1 in 10,000 patients include transient bronchospasm, cough or wheezing, dryness of throat, laryngeal edema, swollen parotid gland, angioedema, joint swelling and pain, dizziness, dysuria, nausea, headache, nasal congestion, rash, and urticaria.

storage

Store at RT

Cromolyn Disodium Salt(15826-37-6)Related Product Information

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• Sodium Cromoglicate Impurity 13
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• Cromolyn Sodium
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