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L-NORADRENALINE BITARTRATE
L-NORADRENALINE BITARTRATE Basic information
- Product Name:
- L-NORADRENALINE BITARTRATE
- Synonyms:
-
- L-Arterenol hydrogen L-tartrate
- L-Norepinephrine bitartrate salt
- Levarterenol bitartrate monohydrate
- 4-[(1R)-2-amino-1-hydroxyethyl]-1,2-Benzenediol (2R,3R)-2,3-dihydroxybutanedioate hydrate (1:1:1)
- L-NORADRENALINE BITARTRATE
- L-(-)-NOREPINEPHRINE-(+)-BITARTRATE
- L-NOREPINEPHRINE BITARTRATE
- L-ARTERENOL BITARTRATE
- CAS:
- 108341-18-0
- MF:
- C12H17NO9
- MW:
- 319.27
- EINECS:
- 627-941-5
- Product Categories:
-
- Levophed
- Aromatics
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
- Steroids
- Mol File:
- 108341-18-0.mol
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L-NORADRENALINE BITARTRATE Chemical Properties
- Melting point:
- 100-104 °C(lit.)
- refractive index
- -11 ° (C=5, H2O)
- storage temp.
- Refrigerator
- solubility
- H2O: soluble50mg/mL, clear
- pka
- 8.64(at 25℃)
- form
- solid
- color
- white
- optical activity
- [α]20/D 11.5±1°, c = 2% in H2O
- Water Solubility
- water: 1mg/mL
- BRN
- 4078502
- InChI
- InChI=1/C8H11NO3.C4H6O6/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-;1-,2-/s3
- InChIKey
- WNPNNLQNNJQYFA-KBOIKTAVNA-N
- SMILES
- [C@H](C1C=CC(O)=C(O)C=1)(O)CN.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:0,12,17,r|
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Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28-28
- Safety Statements
- 22-26-36/37/39-45-36/37-28
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- DN6750000
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2937901500
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L-NORADRENALINE BITARTRATE Usage And Synthesis
Chemical Properties
White Solid
Uses
Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator. Noradrenaline bitartrate monohydrate (Levophed) also directly stimulates the beta-adrenergic receptors of the heart (beta1-adrenergic receptors), but not th
Uses
A demethylated precursor of epinephrine.
Uses
Demethylated precursor of epinephrine (adrenaline). It is a sympathomimetic hormone produced by the adrenal gland.
Biochem/physiol Actions
Norepinephrine bitartrate plays an important role in in vivo and in vitro development of pathogenic and indigenous bacteria. It acts as a vasoconstrictor and adrenergic neurotransmitter.
in vivo
Norepinephrine bitartrate monohydrate can be used to induce cardiomyopathy[5][6]
Induced Cardiomyopathy Model[5][6]
Background
Norepinephrine bitartrate monohydrate is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine bitartrate monohydrate in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine bitartrate monohydrate activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.
Specific Modeling Methods
Rat: Spragues-Dawley rats ? adult (6 months old) ? male
Administration: Continuously injected via an osmotic minipump ? 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)
Modeling Indicators
Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓
Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑
Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.
Correlated Product(s): /
Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)
IC 50
α1-adrenergic receptor; α2-adrenergic receptor; Beta-1 adrenergic receptor; Microbial Metabolite; Human Endogenous Metabolite
L-NORADRENALINE BITARTRATESupplier
Xinxiang City Oran Biotechnology Co. Ltd. Gold
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- 0373-6766851 18568539857
- alchemic516@163.com
Zhejiang Boxiao Bio-Pharmaceutical Co., Ltd. Gold
- Tel
- 0571-63280982
- Helena_Huang@bx-biopharm.com
Shandong Shengzhiyuan Biotechnology Co., LTD Gold
- Tel
- 15064083436
- szyyy01@163.com
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
- Tel
- 022-60189726 18812034280
- 188120342808@163.com
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
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L-NORADRENALINE BITARTRATE(108341-18-0)Related Product Information
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- L-NORADRENALINE HYDROCHLORIDE
- Methyltransferase, noradrenaline N-
- N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE
- DL-NORADRENALINE,DL-NORADRENALINE 98+%
- (-)-NORADRENALINE,NORADRENALINE,d-(-)-noradrenalin
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- N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE
- L-NORADRENALINE BITARTRATE
- L-ADRENALINE BITARTRATE
- Norepinephrine Bitartrate