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4-Iodotoluene

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4-Iodotoluene Basic information

Product Name:
4-Iodotoluene
Synonyms:
  • 1-IODO-4-METHYLBENZENE
  • AURORA KA-7367
  • IODOTOLUENE(4-)
  • 4-Iodotouene
  • 4-Iodotoluene,>98%
  • 4-IODOTOLUENE
  • 4-Iodotoluene 98%
  • 4-IODOTOLUENE 99.5%
CAS:
624-31-7
MF:
C7H7I
MW:
218.04
EINECS:
210-841-7
Product Categories:
  • alkyl Iodine
  • Aryl
  • Building Blocks
  • C7
  • Chemical Synthesis
  • Halogenated Hydrocarbons
  • Aromatic Hydrocarbons (substituted) & Derivatives
  • Halogen toluene
  • Iodine Compounds
  • Pharmaceutical Intermediate
  • Organic Building Blocks
  • Pyridines ,Halogenated Heterocycles
  • bc0001
Mol File:
624-31-7.mol
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4-Iodotoluene Chemical Properties

Melting point:
33-35 °C (lit.)
Boiling point:
211.5 °C (lit.)
Density 
1,678 g/cm3
refractive index 
1.6155 (estimate)
Flash point:
194 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Solubility in methanol is almost transparent.
form 
Crystalline Low Melting Mass
color 
White to light yellow
Water Solubility 
insoluble
Sensitive 
Light Sensitive
BRN 
1903637
InChIKey
UDHAWRUAECEBHC-UHFFFAOYSA-N
CAS DataBase Reference
624-31-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-iodo-4-methyl-(624-31-7)
EPA Substance Registry System
Benzene, 1-iodo-4-methyl- (624-31-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/38-36/37/38
Safety Statements 
24/25-26
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29036990

MSDS

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4-Iodotoluene Usage And Synthesis

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE LOW MELTING MASS

Uses

suzuki reaction

Uses

4-Iodotoluene is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 691, 1987 DOI: 10.1021/jo00380a041
Synthesis, p. 572, 1980 DOI: 10.1055/s-1980-29128

General Description

4-Iodotoluene undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium. Cobalt-catalyzed coupling of 4-iodotoluene with thiophenols and alkanethiols has been investigated. Palladium/copper-catalyzed Sonogashira cross-coupling reaction of 4-iodotoluene with phenylacetylene has been studied.

Purification Methods

Crystallise 4-iodotoluene from EtOH and.or distil it. [Beilstein 5 IV 840.]

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