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Tricin

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Tricin Basic information

Product Name:
Tricin
Synonyms:
  • TRICIN
  • 3',5'-DIMETHOXY-4',5,7-TRIHYDROXYFLAVONE
  • 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-chromen-4-one
  • 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromen-4-one
  • Tricetin 3',5'-dimethyl ether
  • 4',5,7-Trihydroxy-3',5'-dimethoxyflavone
  • 5,7,4'-Trihydroxy-3',5'-dimethoxyflavone
  • 5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
CAS:
520-32-1
MF:
C17H14O7
MW:
330.29
Product Categories:
  • Penta-substituted Flavones
  • API intermediates
Mol File:
520-32-1.mol
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Tricin Chemical Properties

Melting point:
289~291℃
Boiling point:
598.5±50.0 °C(Predicted)
Density 
1.483±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Dichloromethane (Slightly), DMSO (Slightly)
form 
Solid
pka
6.48±0.40(Predicted)
color 
Yellow to Dark Yellow
InChI
InChI=1S/C17H14O7/c1-22-14-3-8(4-15(23-2)17(14)21)12-7-11(20)16-10(19)5-9(18)6-13(16)24-12/h3-7,18-19,21H,1-2H3
InChIKey
HRGUSFBJBOKSML-UHFFFAOYSA-N
SMILES
C1(C2=CC(OC)=C(O)C(OC)=C2)OC2=CC(O)=CC(O)=C2C(=O)C=1
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Tricin Usage And Synthesis

Chemical Properties

Yellow crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the whole herb of Medicago sativa.

Uses

Tricin is a type of flavanoid studied for its immunomodulatory effects.

Definition

ChEBI: The 3',5'-di-O-methyl ether of tricetin. Known commonly as tricin, it is a constituent of rice bran and has been found to potently inhibit colon cancer cell growth.

in vivo

Tricin (50-250 ppm diet; 15 weeks) significantly lowers the numbers of adenocarcinomas and total tumors in mice[5].

target

TLR | p38MAPK | JNK | NF-kB | Phospholipase (e.g. PLA) | Tyrosinase | COX | JAK | STAT | Antifection

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