5-Bromo-3-cyano-2-hydroxypyridine Chemical Properties

Melting point:

219-221

Boiling point:

292.1±40.0 °C(Predicted)

Density 

1.84±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

solid

pka

6.87±0.10(Predicted)

color 

Beige

InChI

InChI=1S/C6H3BrN2O/c7-5-1-4(2-8)6(10)9-3-5/h1,3H,(H,9,10)

InChIKey

SWTLLSLCDHXNIU-UHFFFAOYSA-N

SMILES

C1(=O)NC=C(Br)C=C1C#N

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT

HS Code 

2933399990

5-Bromo-3-cyano-2-hydroxypyridine Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile from 2-oxo-1,2-dihydropyridine-3-carbonitrile: 2-oxo-1,2-dihydropyridine-3-carbonitrile (50 mg, 0.42 mmol) and sodium acetate (69 mg, 0.84 mmol) were dissolved in 5 mL of glacial acetic acid at room temperature, and stirred until complete dissolution. Subsequently, bromine (21.5 μL, 0.42 mmol) was slowly added to the solution and the reaction lasted for 2 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the acetic acid. The crude product was purified by column chromatography (using ethyl acetate as eluent) to afford 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile (69 mg, 75% yield) as a yellow solid. Melting point: 216~217°C. 1H NMR (400MHz, CD3COCD3): δ11.70 (s, 1H), 8.22 (d, J = 2.8Hz, 1H), 8.05 (d, J = 2.8Hz, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 23, p. 6578 - 6581
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 9, p. 1577 - 1580
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5578 - 5585
[5] Patent: US2004/19052, 2004, A1. Location in patent: Page/Page column 17

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• SPECS AO-801/41077573