ETHYLHYDROCUPREINE HYDROCHLORIDE
ETHYLHYDROCUPREINE HYDROCHLORIDE Basic information
- Product Name:
- ETHYLHYDROCUPREINE HYDROCHLORIDE
- Synonyms:
-
- OPTICHIN HYDROCHLORIDE
- ETHYLHYDROCUPREINE HYDROCHLORIDE
- hydrocupreine,ethylester,hydrochloride
- Ethylhydrocupreine HCl,Optochin HCl
- neumolisina
- numoquinhydrochloride
- o-ethyl-hydrocupreinhydrochloride
- optochinhydrochloride
- CAS:
- 3413-58-9
- MF:
- C21H29ClN2O2
- MW:
- 376.92
- EINECS:
- 222-302-3
- Product Categories:
-
- Miscellaneous
- Mol File:
- 3413-58-9.mol
ETHYLHYDROCUPREINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 121-123°C
- alpha
- D21 -123.6° (water)
- storage temp.
- 2-8°C
- solubility
- DMSO : 125 mg/mL (331.64 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
- Sensitive
- Light Sensitive
- BRN
- 4055970
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- RTECS
- MW6300000
- F
- 8
- HS Code
- 29392900
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
ETHYLHYDROCUPREINE HYDROCHLORIDE Usage And Synthesis
Uses
Ethylhydrocupreine Hydrochloride is a reagent used in the alteration in bacterial morphology. Also, it inhibits methylene blue (MB) reductase activity; Anti-pneumococcal analog of quinine-HC1 which stimulated the diaphorase activity of pig heart muscle and Escherichia coli lipoyl dehydrogenase.
in vivo
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1].
IC 50
Plasmodium
Purification Methods
Recrystallise it from H2O [UV: Heidt & Forbes J Am Chem Soc 55 2701 1933]. [Beilstein 24 H 385, 24 III/IV 1446.]
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