5-Fluoro-2-oxindole Chemical Properties

Melting point:

143-147 °C (lit.)

Boiling point:

307.2±42.0 °C(Predicted)

Density 

1.311±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

12.99±0.20(Predicted)

form 

Powder or Crystalline Powder

color 

White to pale brown

InChIKey

DDIIYGHHUMKDGI-UHFFFAOYSA-N

CAS DataBase Reference

56341-41-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

36/37/38-34

Safety Statements 

22-24/25-45-36/37/39-27-26

WGK Germany 

3

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT, KEEP COLD

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

5-Fluoro-2-oxindole Usage And Synthesis

Chemical Properties

Light Yellow Crystalline

Uses

5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.

Application

5-Fluoro-2-oxindole is a ketone organic compound that can be used as an intermediate in the preparation of sunitinib. Sunitinib is a novel multi-targeted oral drug for the treatment of tumors.

Preparation

synthesis of 5-fluoro-2-oxindole: 4-fluoroaniline was used as the starting material, reacted with chloral hydrate and hydroxylamine hydrochloride to generate 4-fluoroisonitrosoacetanilide, and then cyclized under the action of concentrated sulfuric acid to form the compound 5-fluoroisatin was finally obtained by wolff-kishner-huang minlon reduction to obtain 5-fluoro-2-oxindole with a total yield of 66%.

5-Fluoro-2-oxindole(56341-41-4)Related Product Information

• Naringin dihydrochalcone
• Oxindole
• 4-Fluoroacetophenone
• 5-Fluoroindole
• Indole-3-butyric acid
• Fluorochloridone
• 4'-(Trifluoromethyl)acetophenone
• Indole-3-acetic acid
• cis-Octahydroisoindole
• Fluridone
• 1-(2,6-Dichlorophenyl)indolin-2-one
• Isophorone
• Dehydroepiandrosterone
• Indometacin
• 7-FLUORO-2-OXINDOLE
• 3-Amino-5-fluoropyridine
• Sunitinib N-Oxide
• Sunitinib Impurity B