5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Chemical Properties

Melting point:

166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2))

Boiling point:

681.6±65.0 °C(Predicted)

Density 

1.13±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly)

form 

Solid

pka

0.30±0.10(Predicted)

color 

Off-White

CAS DataBase Reference

124750-53-4(CAS DataBase Reference)

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Usage And Synthesis

Chemical Properties

Off-white Solid

Uses

An intermediate in the preparation of labelled Candesartan.

Uses

5-?(4''-?Methyl-?[1,?1''-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole is a reactant in the synthesis of anti-microbial agents.

Synthesis

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole(124750-53-4)Related Product Information

• Triphenylmethyl Chloride
• Trityl candesartan
• Trityl Irbesartan
• Trityl candesartan cilexetil
• 4,4'-Dimethylbiphenyl
• 2,3,5-Triphenyltetrazolium chloride
• Silicone oil (high temperature)
• Chlorodimethylphenylsilane
• Trityl olmesartan
• 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
• 2-Butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole
• 4-Phenyltoluene
• methylphenyl silicone resin
• Benzyl N-[(2(Trityltetrazol-5-yl-1,1biphenyl-4-yl]-methyl-2-amino-3-methylbutanoate
• 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole
• AKOS 91708
• AKOS 91707