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6-(Trifluoromethyl)nicotinic acid

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6-(Trifluoromethyl)nicotinic acid Basic information

Product Name:
6-(Trifluoromethyl)nicotinic acid
Synonyms:
  • 6-(TRIFLUOROMETHYL)NICOTINIC ACID
  • 3-Pyridinecarboxylicacid, 6-(trifluoroMethyl)-
  • 6- threefluorine Methylnicotinate
  • 6-(Trifluoromethyl)pyridine-3-carboxylic acid, 5-Carboxy-2-(trifluoromethyl)pyridine
  • 6-Trifluoromethylnicotic acid
  • 6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID
  • 2-TRIFLUOROMETHYL-5-PYRIDINECARBOXYLIC ACID
  • RARECHEM AL BO 1001
CAS:
231291-22-8
MF:
C7H4F3NO2
MW:
191.11
EINECS:
624-411-5
Product Categories:
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Acids and Derivatives
  • Nitrogen cyclic compounds
  • Pyridine Series
  • Heterocycles
  • Aromatics
  • Carboxylic Acids
  • Pyridines
  • Pyridine
  • Niacin
  • Pyridines derivates
  • Heterocycle
  • Carboxylic Acids
  • Building Blocks
Mol File:
231291-22-8.mol
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6-(Trifluoromethyl)nicotinic acid Chemical Properties

Melting point:
193-197 °C(lit.)
Boiling point:
259.3±40.0 °C(Predicted)
Density 
1.484±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Acetonitrile (Slightly), Methanol (Slightly)
form 
Solid
pka
2.96±0.10(Predicted)
color 
Pale Beige to Light Brown
InChI
InChI=1S/C7H4F3NO2/c8-7(9,10)5-2-1-4(3-11-5)6(12)13/h1-3H,(H,12,13)
InChIKey
JNYLMODTPLSLIF-UHFFFAOYSA-N
SMILES
C1=NC(C(F)(F)F)=CC=C1C(O)=O
CAS DataBase Reference
231291-22-8(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990

MSDS

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6-(Trifluoromethyl)nicotinic acid Usage And Synthesis

Physical properties

6-Trifluoromethylnicotinic acid is a white powder with a melting point of 193-197 °C. It has a boiling point of 259.3℃ at 760 mmHg. Its density is 1.484 g/cm3. Its flash point, refractive index and vapor pressure are 110.6℃, 1.475 and 0.007mmHg at 25°C, respectively.

Uses

6-Trifluoromethyl Nicotinic Acid can be prepared to use Raf inhibitors to treat cancer.

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