4,4'-Dimethoxytrityl chloride Chemical Properties

Melting point:

123-125 °C

Boiling point:

455.07°C (rough estimate)

Density 

1.0887 (rough estimate)

vapor pressure 

0Pa at 20℃

refractive index 

1.5330 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Powder

color 

Pink

Water Solubility 

Soluble in chloroform and methanol. Partially soluble in water

Sensitive 

Moisture Sensitive

BRN 

2471942

Stability:

Hygroscopic, Moisture Sensitive

InChIKey

JBWYRBLDOOOJEU-UHFFFAOYSA-N

LogP

5.74 at 20℃

CAS DataBase Reference

40615-36-9(CAS DataBase Reference)

NIST Chemistry Reference

Methane, chlorobis(p-methoxyphenyl)phenyl-(40615-36-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-34

Safety Statements 

22-24/25-37/39-26-36-45-36/37/39

RIDADR 

3261

WGK Germany 

3

F 

10-21

HS Code 

29093090

Toxicity

A hallucinogenic (psychedelic) agent that may catalyze the onset of emotional problems or psychosis in predisposed individuals. DMT is perhaps one of the least studied of the hallucinogens. It causes perceptual alterations and illusions, including changes in touch, taste, and odor. The thinking process is substantially altered; there are hallucinations and loss of contact with reality. There have been no overdose deaths attributed to the direct effects of DMT. The drug is very short-acting, with a duration of effect of about half an hour or less.

MSDS

• Language:English Provider:Di-p-anisylphenylmethyl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4,4'-Dimethoxytrityl chloride Usage And Synthesis

Chemical Properties

4,4'-Dimethoxytrityl chloride is pink powder

Uses

4,4'-Dimethoxytrityl chloride is a versatile protecting group for primary alcohols, specially useful in oligonucleotide synthesis

Uses

4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.

Uses

Hydroxyl protecting group for nucleosides and nucleotides.

Flammability and Explosibility

Not classified

Purification Methods

DMT crystallises from cyclohexane/acetyl chloride as the hydrochloride. Dry it over KOH pellets in a desiccator. When dissolved in *C6H6 and air is blown through, HCl is removed. It crystallises from Et2O. [Baeyer & Villiger Chem Ber 36 2788 1903, Smith et al. J Am Chem Soc 84 430 1962, Smith et al. J Am Chem Soc 85 3821 1963.] Ifit has hydrolysed considerably (see OH in IR), then repeat the crystallisation from cyclohexane/acetyl chloride — excess of AcCl is removed in a vacuum over KOH, then recrystallise it from Et2O. [Beilstein 6 IV 1042.]

4,4'-Dimethoxytrityl chloride(40615-36-9)Related Product Information

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• TRIPHENYLMETHYL MERCAPTAN
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• (Trifluoromethoxy)benzene
• Ammonium chloride
• p-Anisaldehyde
• Triphenylphosphine
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• m-Anisyl alcohol
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• Chloromethane
• Anisole
• Calcium chloride
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