(-)-8-PHENYLMENTHOL Chemical Properties

Boiling point:

130 °C (0.7501 mmHg)

alpha 

-26°(20/D, c=2, C2H5OH)

Density 

0.999 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.53(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Methanol (Very Slightly)

pka

15.21±0.60(Predicted)

form 

Viscous Liquid

color 

Clear colorless to light yellow

Specific Gravity

0.999

optical activity

[α]20/D 26°, c = 2 in ethanol

λmax

259nm(CH2Cl2)(lit.)

BRN 

3651167

CAS DataBase Reference

65253-04-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-8-10

HS Code 

29061900

MSDS

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• Language:English Provider:ACROS

(-)-8-PHENYLMENTHOL Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS OILY LIQUID

Uses

(-)-8-Phenylmenthol is used to prepare piperidine-based analogs of cocaine as monoamine reuptake inhibitors. It is also used to prepare quinuclidinyl (fluoroalkyl)benzilate as muscarinic receptor antagonist.

Purification Methods

Dissolve the menthol in toluene, dry (Na2SO4), evaporate and chromatograph it on a silica gel column and eluting with 5% Et2O in pet ether to give an oil with the desired rotation. IR has max 3420cm-1 (OH) with consistent 1H NMR [Corey & Ensley J Org Chem 43 1610 1978, Whitesell et al. Tetrahedron 42 2993 1986, Bednarski & Danishefsky J Am Chem Soc 108 7060 1986].

(-)-8-PHENYLMENTHOL(65253-04-5)Related Product Information

• (+)-8-PHENYLMENTHOL
• 2,5-DIMETHYLCYCLOHEXANOL
• (-)-TRANS-2-TERT-BUTYLCYCLOHEXANOL
• L-Menthol
• 4-Phenyl-2-butanol
• (R)-(-)-4-PHENYL-2-BUTANOL
• 7-PHENYL-1-HEPTANOL
• (+)-8-PHENYLMENTHYL CHLOROACETATE
• (-)-8-PHENYLMENTHOL
• 3-PHENYL-1-BUTANOL
• 2-ETHYLCYCLOHEXANOL
• DL-Menthol