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LUPENONE

Basic information Safety Supplier Related

LUPENONE Basic information

Product Name:
LUPENONE
Synonyms:
  • Aids-082905
  • LUPENONE
  • 18-LUPEN-3-ONE
  • -en-3-one
  • Lup-20(29)
  • LUPENONE(RG)
  • 5α-Lup-20(29)-en-3-one
  • Lup-20(29)-en-3-one
CAS:
1617-70-5
MF:
C30H48O
MW:
424.7
Product Categories:
  • Building block
Mol File:
1617-70-5.mol
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LUPENONE Chemical Properties

Melting point:
165-167°C
Boiling point:
485.7±14.0 °C(Predicted)
Density 
1.115 g/cm3(Temp: 18 °C)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White
LogP
10.400 (est)
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Safety Information

Hazard Codes 
Xi
HS Code 
29142990
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LUPENONE Usage And Synthesis

Chemical Properties

White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dandelion, bamboo leaves and Adenophora australis.

Uses

Lupenone is a lupane triterpenoid with antioxidant and anticholinesterase activity. It also a potential protein tyrosine phosphatase 1B (PTP1B) inhibitor.

Definition

ChEBI: A natural product found in Cupania cinerea.

in vivo

Lupenone (6, 12, 24 mg/kg/day, gavage for 6 weeks) improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/ CTGF-related fibrosis[2].

Animal Model:Spontaneous type 2 diabetic nephropathy db/db mouse models[1]
Dosage:6, 12, 24 mg/kg
Administration:i.g.
Result:Maintained the fasting blood glucose.
Reduced glycosylated hemoglobin, insulin, and 24 h proteinuria levels.
Regulated changes in biochemical indicators

IC 50

Trypanosoma

LUPENONESupplier

J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Email
market03@meryer.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Email
cdhxsj@163.com
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
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LUPENONE(1617-70-5)Related Product Information