4-METHYLESCULETIN Chemical Properties

Melting point:

274-276 °C(lit.)

Boiling point:

248.14°C (rough estimate)

Density 

1.0825 (rough estimate)

refractive index 

1.4440 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMF: soluble

pka

8.72(at 25℃)

form 

powder

color 

Light brown

PH Range

Colorless (4.0) to blue 1 uorescent (6.2)

λmax

348nm, 292nm

BRN 

162550

Major Application

Electroluminescent device, photoresists, photography, analytical reagent, cosmetics, hair dye, shampoo, antioxidant, hypotensive agent, antiimfiammatroy agent, antiviral agent, multidrug resistance (MDR) modulator, inhibitory effect onmelanin biosynthesis, protective agent against DNA damage, antimutagenic agent, detection of tumor cell-specific cytotoxicity, antiproliferative againt against cancer cells, analysis of human pancreatice cancer cell activity, chondroprotective agent

LogP

0.959 (est)

CAS DataBase Reference

529-84-0(CAS DataBase Reference)

EPA Substance Registry System

4-Methylesculetin (529-84-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

2

RTECS 

GN6384500

F 

8

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29322985

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-METHYLESCULETIN Usage And Synthesis

Chemical Properties

GREY POWDER

Uses

6,7-Dihydroxy-4-methylcoumarin is suitable as a pH-indicator.

Definition

ChEBI: 6,7-dihydroxy-4-methylcoumarin is a hydroxycoumarin that is 4-methylcuomarin which is substituted by hydroxy groups at positions 3 and 4. A hyaluronan synthesis inhibitor. It has also been used as a fluorescent sensor to monitor the consumption of a boronic acid in Suzuki coupling reactions; fluorescence is readily detectable by the naked eye using a standard 365 nm UV lamp. It has a role as a hyaluronan synthesis inhibitor, an antioxidant and an anti-inflammatory agent.

4-METHYLESCULETIN(529-84-0)Related Product Information

• 6-HYDROXY-7-METHOXY-4-PHENYLCOUMARIN
• 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN
• 4-METHYL-6,7-BIS(SULFOXY)-2H-1-BENZOPYRAN-2-ONE DISODIUM SALT TRIHYDRATE
• metescufylline
• 6,7-DIMETHOXY-4-METHYLCOUMARIN
• 4-METHYLESCULETIN
• METHYLESCULETIN, 4-(RG)
• SODIUM METHYLESCULETIN ACETATE
• B-METHYLESCULETIN,6-Methylesculetin,6-O-Methylesculetin,beta-Methylesculetin
• 4-Methylcumarin
• 6,7-DIMETHOXY-4-(TRIFLUOROMETHYL)COUMARIN
• 4-ISOCYANATOMETHYL-6,7-METHYLENEDIOXYCOUMARIN
• 4-METHYL-6,7-METHYLENEDIOXYCOUMARIN
• 4-METHYL 6-HYDROXY 7-ACETOXY COUMARIN
• 6,7-DIETHOXY-4-METHYLCOUMARIN
• NORDALBERGIN
• 6,7-DIACETOXY-4-METHYLCOUMARIN
• 3-MALEIMIDO-4-METHYL-6,7-METHYLENEDIOXYCOUMARIN