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4-METHYLESCULETIN

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4-METHYLESCULETIN Basic information

Product Name:
4-METHYLESCULETIN
Synonyms:
  • 4-METHYLESCULETIN
  • 6,7-DIHYDROXY-4-METHYL-CHROMEN-2-ONE
  • 6,7-DIHYDROXY-4-METHYLCOUMARIN
  • METHYLESCULETIN, 4-
  • methylesculetin
  • 6 7-DIHYDROXY-4-METHYLCOUMARIN FOR &
  • 4-Methylesculetin, 98+%
  • (6,7-Dihydroxy-4-methylcoumarin)4-Methylesculetin
CAS:
529-84-0
MF:
C10H8O4
MW:
192.17
EINECS:
208-470-0
Product Categories:
  • Coumarin
  • Fluorescent
  • Coumarins
Mol File:
529-84-0.mol
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4-METHYLESCULETIN Chemical Properties

Melting point:
274-276 °C(lit.)
Boiling point:
248.14°C (rough estimate)
Density 
1.0825 (rough estimate)
refractive index 
1.4440 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMF: soluble
pka
8.72(at 25℃)
form 
powder
color 
Light brown
PH Range
Colorless (4.0) to blue 1 uorescent (6.2)
λmax
348nm, 292nm
BRN 
162550
Major Application
Electroluminescent device, photoresists, photography, analytical reagent, cosmetics, hair dye, shampoo, antioxidant, hypotensive agent, antiimfiammatroy agent, antiviral agent, multidrug resistance (MDR) modulator, inhibitory effect onmelanin biosynthesis, protective agent against DNA damage, antimutagenic agent, detection of tumor cell-specific cytotoxicity, antiproliferative againt against cancer cells, analysis of human pancreatice cancer cell activity, chondroprotective agent
LogP
0.959 (est)
CAS DataBase Reference
529-84-0(CAS DataBase Reference)
EPA Substance Registry System
4-Methylesculetin (529-84-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
GN6384500
F 
8
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29322985

MSDS

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4-METHYLESCULETIN Usage And Synthesis

Chemical Properties

GREY POWDER

Uses

6,7-Dihydroxy-4-methylcoumarin is suitable as a pH-indicator.

Definition

ChEBI: 6,7-dihydroxy-4-methylcoumarin is a hydroxycoumarin that is 4-methylcuomarin which is substituted by hydroxy groups at positions 3 and 4. A hyaluronan synthesis inhibitor. It has also been used as a fluorescent sensor to monitor the consumption of a boronic acid in Suzuki coupling reactions; fluorescence is readily detectable by the naked eye using a standard 365 nm UV lamp. It has a role as a hyaluronan synthesis inhibitor, an antioxidant and an anti-inflammatory agent.

in vivo

4-Methylesculetin (5 or 25 mg/kg, p.o., daily for 8 days) decreases MPO activity, reduces the colonic levels of IL-6 and counteracts GSH depletion, showing the intestinal antiinflammatory activity in Dextran sulfate sodium (DSS) rat model[1].
4-Methylesculetin (25 and 50 mg/kg, p.o., once a day from 11th day to 25th day) significantly prevents the swelling, bone and cartilage destruction at the joint in arthritic rats[2].

Animal Model:DSS rat model[1]
Dosage:5 or 25 mg/kg
Administration:p.o., daily for 8 days
Result:Reduced MPO activity, IL-6 levels and counteracted GSH depletion induced by inflammatory process.
Animal Model:Arthritic rats[2]
Dosage:25 and 50 mg/kg
Administration:p.o., once a day from 11th day to 25th day
Result:Exhibited remarkable decline in paw volume and showed a prompt recovery of normal weight.

4-METHYLESCULETIN Preparation Products And Raw materials

Raw materials

1,4-Benzoquinone

4-METHYLESCULETINSupplier

J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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Alfa Aesar
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400-6106006
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
Email
Sales-CN@TCIchemicals.com
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