IDRA 21 Chemical Properties

Melting point:

209 °C(Solv: acetic acid (64-19-7))

Boiling point:

405.1±55.0 °C(Predicted)

Density 

1.394±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Sonicated)

form 

Solid

pka

9.78±0.40(Predicted)

color 

Off-White to Pale Yellow

InChIKey

VZRNTCHTJRLTMU-UHFFFAOYSA-N

Safety Information

Safety Statements 

24/25

WGK Germany 

3

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

IDRA 21 Usage And Synthesis

Chemical Properties

white to off-white crystalline powder

Uses

IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.

Uses

IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).

Definition

ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine.

Biological Activity

Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).

storage

Room temperature

IDRA 21(22503-72-6)Related Product Information

• Methyltrichlorosilane
• Benzyl chloride
• Triphosgene
• IDRA 21
• 2-Amino-5-chlorobenzenesulfonamide