GLP-1(7-36) Acetate
GLP-1(7-36) Acetate Basic information
- Product Name:
- GLP-1(7-36) Acetate
- Synonyms:
-
- Human GLP-1-(7-36)-amide Acetate
- GLP-1(7-36) xAcetate
- GLP-1(7-36), amide acetate ，P1120
- CAS:
- 1119517-19-9
- MF:
- C151H230N40O47
- MW:
- 3357.73
- Mol File:
- 1119517-19-9.mol
GLP-1(7-36) Acetate Chemical Properties
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water : 16.6 mg/mL
- Sequence
- His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
GLP-1(7-36) Acetate Usage And Synthesis
Uses
GLP-1(7-36), amide acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.
in vivo
Gastric administration of glucose increases active GLP-1(7-36) amide levels in the portal blood after 10 min, followed by a marked decrease at 30 min. The gastric administration of TO also increases active GLP-1 levels after 10 min, and followed by a decrease to basal levels at 60 min. Individually, glucose and TO increase the secretion of GLP-1 in a dose-dependent manner. Furthermore, the co-administration of glucose and TO additively increase peak GLP-1 levels. CPE-administered mice have higher active GLP-1 levels in the portal blood at 10 and 30 min than those in the control mice. When glucose is administered with CPE, active GLP-1 and insulin levels in the portal blood are slightly higher in CPE-administered mice than in the control mice. High-fat diet-fed C57BL/6J mice develop hyperglycaemia and impair glucose tolerance[1].
References
[1] Fujii Y et al. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1(GLP-1(7-36)) amide in C57BL/6J mice. J Nutr Sci. 2015 Mar 3 DOI:10.1017/jns.2014.71
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