4-Fluorobenzyl bromide Chemical Properties

Boiling point:

85 °C15 mm Hg(lit.)

Density 

1.517 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.547(lit.)

Flash point:

>230 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Chloroform

form 

Liquid

Specific Gravity

1.517

color 

Clear colorless to yellow

Sensitive 

Lachrymatory

BRN 

636507

InChIKey

NVNPLEPBDPJYRZ-UHFFFAOYSA-N

CAS DataBase Reference

459-46-1(CAS DataBase Reference)

NIST Chemistry Reference

«alpha»-Bromo-4-fluorotoluene(459-46-1)

EPA Substance Registry System

4-Fluorobenzyl bromide (459-46-1)

Safety Information

Hazard Codes 

C

Risk Statements 

34-36

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

Hazard Note 

Corrosive/Lachrymatory

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29039990

MSDS

• Language:English Provider:4-Fluorobenzyl bromide
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• Language:English Provider:ACROS
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4-Fluorobenzyl bromide Usage And Synthesis

Chemical Properties

4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.

Uses

4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.

Chemical Properties

Colorless to light yellow liqui

Uses

4-Fluorobenzyl bromide was used in the preparation of:

• 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
• 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
• (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
• 8-bromo 9-(4-fluorobenzyl) adenine
• 8-bromo 3-(4-fluorobenzyl) adenine

Uses

4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.

4-Fluorobenzyl bromide(459-46-1)Related Product Information

• Rocuronium bromide
• [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate
• Diethylstilbestrol
• Ethyl bromodifluoroacetate
• Fluorobenzene
• Ethidium bromide
• 4-Fluorobenzyl chloride
• BRETYLIUM TOSYLATE
• Allyl bromide
• Sodium bromate
• alpha-Chloro-o-fluorotoluene
• 4-n-Propoxyphenylacetylene
• Bromine
• 1,2-Bis(bromomethyl)benzene
• 9-BROMOFLUORENE
• 2-(Trifluoromethyl)benzyl bromide
• 1,2,4,5-TETRAKIS(BROMOMETHYL)BENZENE
• Methyl bromide