Basic information Chemical Properties Uses Safety Supplier Related
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4-Fluorobenzyl bromide

Basic information Chemical Properties Uses Safety Supplier Related

4-Fluorobenzyl bromide Basic information

Product Name:
4-Fluorobenzyl bromide
Synonyms:
  • P-FLUOROBENZYL BROMIDE
  • 4-Fluoro-1-(bromomethyl)benzene
  • α-Bromo-4-fluorotoluene
  • 4-Fluorobenzyl bromi
  • BroMobenzene of fluoride
  • Of fluoride broMide
  • 1-(Bromomethyl)-4-fluorobenzene, alpha-Bromo-4-fluorotoluene
  • α-BroMo-p-fluorotoluene
CAS:
459-46-1
MF:
C7H6BrF
MW:
189.02
EINECS:
207-291-5
Product Categories:
  • Benzyl
  • Fluoro-contained benzyl bromide series
  • Fluorinated benzene series
  • alkyl bromide|alkyl Fluorine
  • Halogenated Heterocycles ,Pyrimidines
  • bc0001
Mol File:
459-46-1.mol
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4-Fluorobenzyl bromide Chemical Properties

Boiling point:
85 °C15 mm Hg(lit.)
Density 
1.517 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.547(lit.)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Chloroform
form 
Liquid
Specific Gravity
1.517
color 
Clear colorless to yellow
Sensitive 
Lachrymatory
BRN 
636507
InChIKey
NVNPLEPBDPJYRZ-UHFFFAOYSA-N
CAS DataBase Reference
459-46-1(CAS DataBase Reference)
NIST Chemistry Reference
«alpha»-Bromo-4-fluorotoluene(459-46-1)
EPA Substance Registry System
4-Fluorobenzyl bromide (459-46-1)
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Safety Information

Hazard Codes 
C
Risk Statements 
34-36
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive/Lachrymatory
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29039990

MSDS

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4-Fluorobenzyl bromide Usage And Synthesis

Chemical Properties

4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.

Uses

4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.

Chemical Properties

Colorless to light yellow liqui

Uses

4-Fluorobenzyl bromide was used in the preparation of:

  • 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
  • 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
  • (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
  • 8-bromo 9-(4-fluorobenzyl) adenine
  • 8-bromo 3-(4-fluorobenzyl) adenine

Uses

4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.

4-Fluorobenzyl bromideSupplier

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