CALCISEPTINE Chemical Properties

storage temp. 

-20°C

Sequence

Arg-Ile-Cys-Tyr-Ile-His-Lys-Ala-Ser-Leu-Pro-Arg-Ala-Thr-Lys-Thr-Cys-Val-Glu-Asn-Thr-Cys-Tyr-Lys-Met-Phe-Ile-Arg-Thr-Gln-Arg-Glu-Tyr-Ile-Ser-Glu-Arg-Gly-Cys-Gly-Cys-Pro-Thr-Ala-Met-Trp-Pro-Tyr-Gln-Thr-Glu-Cys-Cys-Lys-Gly-Asp-Arg-Cys-Asn-Lys (Disulfide bridge:Cys3-Cys22;Cys17-Cys39;Cys41-Cys52; Cys53-Cys58)

CALCISEPTINE Usage And Synthesis

Uses

Calciseptine, a natural?neurotoxin?isolated from the black mamba Dendroaspis p. polylepis venom. Calciseptine consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-type?calcium channel[1].

IC 50

L-type calcium channel: 15 nM (IC₅₀)

References

[1] H Schweitz, et al. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3): 878–882. DOI:10.1073/pnas.91.3.878

CALCISEPTINE(178805-91-9)Related Product Information

• Toxins and Analogues
• ODK2
• KURTOXIN
• ODK2 analogues
• μ-conotoxin GlllA
• SHK TOXIN
• OMEGA-AGATOXIN IVA
• SSD609
• HUWENTOXIN IV
• mu-conotoxin
• PLTX-ll
• ω-conotoxin MVllA
• Dendrotoxin-l
• ω-agatoxin IVB
• SNX-482
• Mambalgin-3
• a-conotoxin lml
• CALCISEPTINE,CALCISEPTINE, DENDROASPIS POLYLEPIS POLYLEPIS