TRIS(DIMETHYLAMINO)METHANE Chemical Properties

Boiling point:

42-43 °C/12 mmHg (lit.)

Density 

0.838 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.436(lit.)

Flash point:

4 °F

storage temp. 

2-8°C

form 

Liquid

pka

6.50±0.38(Predicted)

color 

Clear colorless to slightly yellow

BRN 

1901162

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-34

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2733 3/PG 2

WGK Germany 

3

F 

3-8-10-21

Hazard Note 

Corrosive/Highly Flammable

HazardClass 

3.1

PackingGroup 

II

HS Code 

29212900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

TRIS(DIMETHYLAMINO)METHANE Usage And Synthesis

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Reagent for the introduction of the dimethylaminoethylidene group.1 General review;2 RO polymerization of lactide.3

Uses

N,N,N'',N'',N'''',N''''-Hexamethylmethanetriamine, can be used in the synthesis of the phosphoramidite derivative of the new nucleoside analog. It can also be used as reagent for the introduction of the dimethylaminoethylidene group.

Uses

Tris(dimethylamino)methane was used:

• to prepare the phosphoramidite derivative of the new nucleoside analog
• as reagent for the introduction of the dimethylaminoethylidene group
• in ring-opening (RO) polymerization of lactide

General Description

NMR spectra and their temperature-dependence has been reported for tris(dimethylamino)methane. Tris(dimethylamino)methane reacts with crowded α-(o-nitrophenyl) ketone to yield tetrahydroquinoline derivative.

Purification Methods

Dry it over KOH and distil it through a Vigreux column (p 11) at water pump vacuum. Store it in the absence of CO2. [Bredereck et al. Chem Ber 101 1885 1968 and Angew Chem, Int Ed Engl 5 132 1966.]

TRIS(DIMETHYLAMINO)METHANE(5762-56-1)Related Product Information

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• TRIS(DIMETHYLAMINO)METHANE