Darifenacin 3-Hydroxy Impurity Chemical Properties

Boiling point:

644.1±55.0 °C(Predicted)

Density 

1.247±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: soluble; Methanol: soluble

form 

A solid

pka

13.52±0.20(Predicted)

Darifenacin 3-Hydroxy Impurity Usage And Synthesis

Description

3-hydroxy Darifenacin is a metabolite of darifenacin . It is an antagonist of M_1-5 muscarinic receptors (K_is = 17.78, 79.43, 2.24, 36.31, and 6.17 nM, respectively, in CHO cells).

Uses

3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells[1].

References

[1] Mansfield KJ, et al. Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa. J Pharmacol Exp Ther. 2009 Mar;328(3):893-9. DOI:10.1124/jpet.108.145508

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