2-Thiopheneglyoxylic acid Chemical Properties

Melting point:

88-91 °C (lit.)

Boiling point:

250.38°C (rough estimate)

Density 

1.404 (estimate)

refractive index 

1.5151 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

2.09±0.54(Predicted)

Sensitive 

Hygroscopic

BRN 

115791

CAS DataBase Reference

4075-59-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34

Safety Statements 

26-27-28-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

III

HS Code 

29349990

MSDS

• Language:English Provider:2-Thiopheneglyoxylic acid
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2-Thiopheneglyoxylic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2-Thiopheneglyoxylic acid was used in the synthesis of europium complexes.

Synthesis

The general procedure for the synthesis of 2-thiophene glyoxalate from ethyl thiophene-2-glyoxalate was as follows: to a solution of ethyl thiophene-2-glyoxalate (4 mL, 27.17 mmol) in ethanol (60 mL) was added an aqueous 4N sodium hydroxide solution (10.2 mL, 40.76 mmol). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction solution was acidified with 2N aqueous hydrochloric acid to pH 2. Subsequently, the solvent was removed by vacuum distillation to afford 2-thiophene glyoxalic acid as a yellow solid product (quantitative yield). The resulting residue was used directly in the subsequent reaction without further purification.LCMS analysis (Method 2): [MH-] = 155 with a retention time of 0.71 min.

References

[1] Patent: WO2016/193244, 2016, A1. Location in patent: Page/Page column 80
[2] Chemical Communications, 2014, vol. 50, # 34, p. 4489 - 4491
[3] Patent: WO2016/177849, 2016, A1. Location in patent: Page/Page column 60
[4] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4184 - 4190

2-Thiopheneglyoxylic acid(4075-59-6)Related Product Information

• α-Lipoic Acid
• Citric acid
• Glyoxylic acid
• Cephalothin sodium
• 2-(2-Aminothiazol-4-yl)glyoxylic acid
• SODIUM GLYOXYLATE
• Tetrahydrothiophene
• Ethyl glyoxalate
• Ascoric Acid
• ETHYL THIOPHENE-2-GLYOXYLATE
• 2-Thiopheneacetic acid
• ETHYL 3-METHYLTHIOPHENE-2-GLYOXYLATE
• ETHYL 3-BROMOTHIOPHENE-2-GLYOXYLATE
• ETHYL 2-CHLOROTHIOPHENE-5-GLYOXYLATE
• ETHYL 5-METHYLTHIOPHENE-2-GLYOXYLATE
• ETHYL 5-(1,3-DIOXOLAN-2-YL)-2-THENOYLFORMATE
• ETHYL (5-BROMOTHIEN-2-YL)GLYOXYLATE
• 2-Thiopheneglyoxylic acid