Basic information Safety Supplier Related

NEMONAPRIDE

Basic information Safety Supplier Related

NEMONAPRIDE Basic information

Product Name:
NEMONAPRIDE
Synonyms:
  • CIS-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[2-METHYL-1-(PHENYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE
  • REL-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[(2R,3R)-2-METHYL-2-(PHENNYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE
  • NEMONAPRIDE
  • (+-)-cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylami
  • benzamide,5-chloro-2-methoxy-4-(methylamino)-n-(2-methyl-1-(phenylmethyl)-3-py
  • cis-(+-)-rrolidinyl)
  • emonapride
  • inobenzamide
CAS:
75272-39-8
MF:
C21H26ClN3O2
MW:
387.9
Product Categories:
  • Aromatics
  • Heterocycles
  • Heterocyclic Compounds
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
  • Dopamine receptor
Mol File:
75272-39-8.mol
More
Less

NEMONAPRIDE Chemical Properties

Melting point:
152-153°C
storage temp. 
Store at RT
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
CAS DataBase Reference
75272-39-8
More
Less

NEMONAPRIDE Usage And Synthesis

Description

Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.

Description

Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).

Chemical Properties

Colourless Crystalline Solid

Originator

Yamanouchi (Japan)

Uses

Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.

Uses

A selective dopamine D2 receptor antagonist. Used as an antipsychotic

Definition

ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride.

brand name

Emirace

Biological Activity

Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.

storage

Store at RT

NEMONAPRIDE Preparation Products And Raw materials

Raw materials

NEMONAPRIDESupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com