1,4-Dioxaspiro[4.5]decan-8-one Chemical Properties

Melting point:

70-73 °C (lit.)

Boiling point:

112C

Density 

1.0887 (rough estimate)

refractive index 

1.4430 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Soluble in chloroform & methanol.

form 

Crystalline Powder or Crystals

color 

White to beige

Sensitive 

Moisture Sensitive

BRN 

117631

InChI

InChI=1S/C8H12O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h1-6H2

InChIKey

VKRKCBWIVLSRBJ-UHFFFAOYSA-N

SMILES

O1C2(CCC(=O)CC2)OCC1

CAS DataBase Reference

4746-97-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36/37/39-26

WGK Germany 

3

F 

8-10-21

Hazard Note 

Irritant

HS Code 

29110000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,4-Dioxaspiro[4.5]decan-8-one Usage And Synthesis

Chemical Properties

1,4-Dioxaspiro[4.5]decan-8-one is white to beige crystalline powder or crystals

Uses

1,4-Dioxaspiro[4.5]decan-8-one is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Uses

Intermediates of Liquid Crystals

Uses

1,4-Cyclohexanedione is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

Application

1,4-Dioxaspiro[4.5]decan-8-one can be used:
(1) Used in a study of microwave-assisted reductive amination.
(2) Via a novel aromatization process, this bicyclic frame can be converted into a series of 5-alkoxytryptamine derivatives including serotonin, melatonin and bufotenin.

Purification Methods

Recrystallise it from pet ether. It sublimes slowly on attempted distillation. Also purify it by dissolving it in Et2O and adding pet ether (b 60-80o) until turbid and cooling. [Gardner et al. J Am Chem Soc 22 1206 1957, Britten & Lockwood J Chem Soc Perkin Trans 1 1824 1974.] [Beilstein 19/4 V 93.]

1,4-Dioxaspiro[4.5]decan-8-one(4746-97-8)Related Product Information

• Diethylene glycol
• DIOXOPROMETHAZINE HCL
• 2-Bromomethyl-1,3-dioxolane
• Decane
• Cyclohexanone
• 1,4-Cyclohexanedione
• Buspirone
• Selenium dioxide
• 1,4-Dioxane
• 2,2-DIMETHYL-1,3-DIOXOLANE
• 4-HYDROXYCYCLOHEXANONE
• 1,1-DIMETHOXYCYCLOHEXANE
• 2-METHYL-1,3-DIOXOLANE
• DIOXOPROMETHAZINE
• HEXANAL DIMETHYL ACETAL
• 1,3-Dioxolane
• 2-ETHYL-2-METHYL-1,3-DIOXOLANE
• 3,3-DIMETHOXYHEXANE