3'-SIALYLLACTOSE
3'-SIALYLLACTOSE Basic information
- Product Name:
- 3'-SIALYLLACTOSE
- Synonyms:
-
- 3μ-N-Acetylneuraminyl-D-lactose sodium salt, 3μ-Sialyl-D-lactose, 3μ-SL, NANA-Lactose, α-NeuNAc-(2-3)-β-D-Gal-(1-4)-D-Glc
- NANA-Lactose, Sialyl-D-lactose
- 3-O-(N-Acetyl-α-neuraminosyl)-4-O-(β-D-galactopyranosyl)-D-glucose
- Sia--2, 3-Gal--1,4-Glc
- 3)-O-b-D-galactopyranosyl-(1®
- D-Glucose, O-(N-acetyl-a-neuraMinosyl)-(2®
- 3′-N-Acetylneuraminyl-D-lactose sodium salt
- Sialyl-D-lactose
- CAS:
- 35890-38-1
- MF:
- C23H39NO19
- MW:
- 633.55
- Mol File:
- 35890-38-1.mol
3'-SIALYLLACTOSE Chemical Properties
- Boiling point:
- 1132.8±65.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- pka
- 1.92±0.70(Predicted)
- form
- powder
- color
- white
- biological source
- bovine milk or colostrum
- Water Solubility
- water: 20mg/mL, clear, colorless
- BRN
- 75357
- EPA Substance Registry System
- D-Glucose, O-(N-acetyl-.alpha.-neuraminosyl)-(2.fwdarw.3)-O-.beta.-D-galactopyranosyl-(1.fwdarw.4)- (35890-38-1)
3'-SIALYLLACTOSE Usage And Synthesis
Uses
3′-Sialyllactose is a compound where in the acetylneuraminyl (NANA) unit is connected to the galactosyl unit of lactose at the 3 position. In 6′-sialylactose, this connection is at the 6 position. 3′-Sialyllactose and 6′-Sialyllactose are used to differentiate and characterize binding domains of viruses, such as influenza and rhinitis viruses, that recognize NANA capped cell surface receptors. 3′-Sialyllactose and 6′-sialylactose are used as reference compounds in analytical methods developed to measure their presence in materials such as milk and colostrums.
in vivo
3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1]. 3'-Sialyllactose (500, 1000 and 2000 mg/kg; orally administration; once) induces no micronuclei in the bone marrow cells of mice[3]. 3'-Sialyllactose (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3]. 3'-Sialyllactose shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3].
| Animal Model: | 8-week-old male C57BL/6 mice with medial meniscus surgery[1] |
| Dosage: | 10, 50 and 100 mg/kg |
| Administration: | Oral gavage; 10-100 mg/kg three times a week; for 6 weeks |
| Result: | Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression. |
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