L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE
L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE Basic information
- Product Name:
- L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE
- Synonyms:
-
- tert-butyl (2R)-2-amino-5-carbamimidamidopentanoate hydrochloride
- H-Arg-OtBu.2HCI
- H-L-Arg-OtBu*2HCl
- H-Arg-OtbuHcl
- (S)-tert-butyl 2-amino-5-guanidinopentanoate hydrochloride
- L-Arginine 1,1-dimethylethyl ester dihydrochloride
- L-Arginine,1,1-diMethylethyl ester, hydrochloride (1:2)
- H-Arg-OtBu dihydrochloride
- CAS:
- 87459-72-1
- MF:
- C10H23ClN4O2
- MW:
- 266.77
- Product Categories:
-
- Amino Acids and Derivatives
- Amino Acid Derivatives
- Amino Acid Derivatives
- Amino Acids
- Mol File:
- 87459-72-1.mol
L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE Chemical Properties
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE Usage And Synthesis
Chemical Properties
White to off-white solid
Uses
H-Arg-OtBu (dihydrochloride) is a membrane-targeting antimicrobial. H-Arg-OtBu (dihydrochloride) targets the negatively charged bacterial membrane via a combination of electrostatic and hydrophobic interactions. H-Arg-OtBu (dihydrochloride) can be used for bacterial infections diseases research[1].
in vivo
H-Arg-OtBu (dihydrochloride) (0.3% solutions treated for 3 times per day) has no signs of corneal inflammation and no evidence of an inflammatory response in rabbit corneal wound healing model[1].
H-Arg-OtBu (dihydrochloride) (0.3% solutions treated for 5 times per day) is effective in a mouse model of corneal infection by S. aureus and MRSA[1].
References
[1] Koh JJ, et al, Beuerman RW. Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections. J Med Chem. 2015 Jan 22;58(2):739-52. DOI:10.1021/jm501285x
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