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DAPT

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DAPT Basic information

Product Name:
DAPT
Synonyms:
  • (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester
  • GSI-IX; GSI IX
  • CS-175
  • γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem
  • LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
  • N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester
  • SC-201315
  • (2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester
CAS:
208255-80-5
MF:
C23H26F2N2O4
MW:
432.46
Product Categories:
  • GSI-IX
  • Inhibitor
  • Angiogenesis and Metastasis
  • Protease inhibitor
  • Inhibitors
Mol File:
208255-80-5.mol
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DAPT Chemical Properties

alpha 
+40.0~+47.0°(D/20℃)(c=0.5,DMSO)
Boiling point:
612.2±55.0 °C(Predicted)
Density 
1.213
storage temp. 
2-8°C
solubility 
DMSO: ~18 mg/mL
pka
12.82±0.46(Predicted)
form 
solid
color 
white
Sensitive 
Light Sensitive
InChIKey
DWJXYEABWRJFSP-XOBRGWDASA-N
CAS DataBase Reference
208255-80-5
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29242990
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DAPT Usage And Synthesis

Uses

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells

Uses

A potent and specific inhibitor of γ-secretase.

Uses

DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells.

Biological Activity

Inhibitor of γ -secretase; causes a reduction in A β 40 and A β 42 levels in human primary neuronal cultures (IC 50 values are 115 and 200 nM for total A β and A β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . Does not effect APP α and APP β levels. Blocks Notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

Biochem/physiol Actions

DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE), as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells (hIPSC).

DAPTSupplier

Atop Bio-Tech (Tianjin) Co., Ltd. (Atop) Gold
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J & K SCIENTIFIC LTD.
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