TRAM-34 Chemical Properties

Melting point:

145-147°C

storage temp. 

2-8°C

solubility 

DMSO: ~11 mg/mL

form 

solid

color 

off-white

Water Solubility 

Soluble in DMSO at 2mg/ml. Insoluble in water

CAS DataBase Reference

289905-88-0

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

TRAM-34 Usage And Synthesis

Chemical Properties

Yellow Solid

Definition

ChEBI: TRAM-34 is an organochlorine compound.

Biological Activity

Highly selective blocker of intermediate conductance Ca 2+ -activated K + channels (IK Ca 1, K Ca 3.1) (K d = 20 nM). Exhibits 200-1500-fold selectivity over K V , BK Ca , SK Ca , Na + , CRAC and Cl - channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

Biochem/physiol Actions

TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

storage

+4°C

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