5,7-Dihydroxy-4-phenylcoumarin Chemical Properties

Melting point:

227-233 °C (lit.)

Boiling point:

535.5±19.0 °C(Predicted)

Density 

1.443

storage temp. 

Store at -20°C

solubility 

DMSO: 250 mg/mL (983.32 mM)

pka

7.09±0.20(Predicted)

form 

Solid

color 

Light yellow to yellow

InChI

InChI=1S/C15H10O4/c16-10-6-12(17)15-11(9-4-2-1-3-5-9)8-14(18)19-13(15)7-10/h1-8,16-17H

InChIKey

HUQKUJNSVHEHIH-UHFFFAOYSA-N

SMILES

C1(=O)OC2=CC(O)=CC(O)=C2C(C2=CC=CC=C2)=C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

5,7-Dihydroxy-4-phenylcoumarin Usage And Synthesis

Uses

LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].

References

[1] Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30. DOI:10.1038/s41586-019-1722-1

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