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OXIDIZED NIFEDIPINE

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OXIDIZED NIFEDIPINE Basic information

Product Name:
OXIDIZED NIFEDIPINE
Synonyms:
  • Nifedipine-1
  • Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridined
  • Nifedipine Impurity Ⅰ:2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester
  • 2,6-Dimethyl-4-(2′-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester, Oxidized Nifedipine
  • Divalproex Sodium Impurity 1
  • Nifedipine Nitrophenylpyridine Analog
  • dimethyl 2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate
  • Nifedipine impurity A (EP)
CAS:
67035-22-7
MF:
C17H16N2O6
MW:
344.32
Product Categories:
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
67035-22-7.mol
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OXIDIZED NIFEDIPINE Chemical Properties

Melting point:
100-105 °C
Boiling point:
443.7±45.0 °C(Predicted)
Density 
1.284±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
powder
pka
1.55±0.29(Predicted)
color 
yellow
EPA Substance Registry System
3,5-Pyridinedicarboxylic acid, 2,6-dimethyl-4-(2-nitrophenyl)-,3,5-dimethyl ester (67035-22-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-39
WGK Germany 
2
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OXIDIZED NIFEDIPINE Usage And Synthesis

Description

Dehydro nifedipine is an active metabolite of nifedipine , a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.

Chemical Properties

Pale Yellow Solid

Uses

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Uses

The main Nifedipine metabolite in human plasma

Definition

ChEBI: Dehydronifedipine is a phenylpyridine.

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

OXIDIZED NIFEDIPINESupplier

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