METHYL 3-THIOPHENECARBOXYLATE 97 Chemical Properties

Boiling point:

98 °C/10 mmHg (lit.)

Density 

1.174 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.5380(lit.)

Flash point:

172 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Light yellow

λmax

239nm(Hexane)(lit.)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

26-36/37

RIDADR 

NA 1993 / PGIII

WGK Germany 

2

HS Code 

29349990

METHYL 3-THIOPHENECARBOXYLATE 97 Usage And Synthesis

Chemical Properties

Colorless to yellow liquid

Synthesis

A catalytic amount of concentrated sulfuric acid (0.5 mL) was added to a solution of 3-thiophenecarboxylic acid (2.0 g, 15.60 mmol) in methanol (30 mL), and the reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was poured into ice-cold water and extracted with ethyl acetate (3 × 20 mL). The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give methyl 3-thiophenecarboxylate (1.8 g, 81% yield) as a colorless oil.

References

[1] Patent: WO2006/123145, 2006, A1. Location in patent: Page/Page column 44
[2] Recueil des Travaux Chimiques des Pays-Bas, 1934, vol. 53, p. 643,648
[3] Recueil des Travaux Chimiques des Pays-Bas, 1936, vol. 55, p. 991
[4] Patent: WO2016/115013, 2016, A1. Location in patent: Page/Page column 70
[5] Patent: WO2006/108701, 2006, A1. Location in patent: Page/Page column 61

METHYL 3-THIOPHENECARBOXYLATE 97(22913-26-4)Related Product Information

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• 5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID
• Methyl 2-aminothiophene-3-carboxylate
• Methyl 3- bromo -2-thiophenecarboxylate