Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antineoplastic agents >  Tinib Antineoplastic drugs >  Lestaurtinib

Lestaurtinib

Basic information Safety Supplier Related

Lestaurtinib Basic information

Product Name:
Lestaurtinib
Synonyms:
  • Lestaurtinib (KT-5555
  • CS-1165
  • lestaurtinib
  • (9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
  • SPM-924
  • CEP-701 hydrate
  • KT-5555 hydrate
  • Lestaurtinib hydrate
CAS:
111358-88-4
MF:
C26H21N3O4
MW:
439.47
Product Categories:
  • Inhibitor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
111358-88-4.mol
More
Less

Lestaurtinib Chemical Properties

Melting point:
215-220°C
Boiling point:
723.0±60.0 °C(Predicted)
Density 
1.70±0.1 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
DMSO: >10mg/mL
form 
white powder
pka
13.37±0.40(Predicted)
Stability:
Photosensitive
More
Less

Safety Information

WGK Germany 
3
More
Less

Lestaurtinib Usage And Synthesis

Chemical Properties

Lestaurtinib is Off-White Solid

Uses

Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)

Uses

It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Biological Activity

Potent JAK2, FLT3 and TrkA inhibitor (IC 50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC 50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC 50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo .

LestaurtinibSupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Email
3bsc@sina.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
BOC Sciences
Email
info@bocsci.com