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(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride

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(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride Basic information

Product Name:
(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride
Synonyms:
  • Famotidine EP Impurity H DiHCl
  • Famotidine Impurity H DiHCl
  • N-[4-[[(amino iminomethyl) thio]-methyl]-2-thiazolyl]-guanidine dihydrochloride (FMT-II)
  • Carbamimidothioic acid [2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl ester dihydrochloride
  • N-(4-(((AMINOIMINOMETHYL)THIO)METHYL)-2-THIAZOLYL)GUANIDINE
  • S-[(2-Guanidino-4-thiazolyl)methyl]isothiourea 2HCl
  • S-[(2-Guanidino-4-thiazolyl)methyl]isothiourea dihydrochloride
  • N-[4-(Aminoiminomethyl)Thiomethyl-2-Thiazolyl]Guanidine Dihydrochloride
CAS:
88046-01-9
MF:
C6H11ClN6S2
MW:
266.77
EINECS:
618-106-6
Product Categories:
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
Mol File:
88046-01-9.mol
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(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride Chemical Properties

Melting point:
>188oC (dec.)
storage temp. 
Refrigerator
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
PH
3.89 at 1000g/L
InChI
InChI=1S/C6H10N6S2.ClH/c7-4(8)12-6-11-3(2-14-6)1-13-5(9)10;/h2H,1H2,(H3,9,10)(H4,7,8,11,12);1H
InChIKey
DMXJVYCDETXZRR-UHFFFAOYSA-N
SMILES
N(C1SC=C(CSC(N)=N)N=1)C(N)=N.Cl
LogP
1 at 30℃ and pH3.89
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(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride Usage And Synthesis

Uses

Famotidine intermediate.

Definition

Famotidine EP Impurity H is chemically (S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride. It is also known as Famotidine Isothiourea Impurity . Famotidine EP Impurity H can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Famotidine.

(S)-((2-Guanidino-4-thiazolyl)methylisothiourea dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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