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POLYPHYLLIN D

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POLYPHYLLIN D Basic information

Product Name:
POLYPHYLLIN D
Synonyms:
  • POLYPHYLLIN D
  • Polyphyllin
  • Polyphyllin I
  • Polyphyllin C
  • Paris saponin Pa
  • Polyphillin D
  • Polyphyllin A
  • Paridis saponin I
CAS:
50773-41-6
MF:
C44H70O16
MW:
855.02
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
50773-41-6.mol
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POLYPHYLLIN D Chemical Properties

Melting point:
>245°C (dec.)
Density 
1.40
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)
pka
12?+-.0.70(Predicted)
form 
Solid
color 
White
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Safety Information

HS Code 
29389090
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POLYPHYLLIN D Usage And Synthesis

Description

Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.

Uses

Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.

POLYPHYLLIN DSupplier

Chembest Research Laboratories Limited
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