POLYPHYLLIN D Chemical Properties

Melting point:

>245°C (dec.)

Density 

1.40

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly)

pka

12?+-.0.70(Predicted)

form 

Solid

color 

White

Safety Information

HS Code 

29389090

POLYPHYLLIN D Usage And Synthesis

Description

Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC₅₀s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.

Uses

Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.

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