NUC-7738 Chemical Properties

Boiling point:

785.0±70.0 °C(Predicted)

Density 

1.52±0.1 g/cm3(Predicted)

pka

13.52±0.60(Predicted)

form 

Solid

color 

White to off-white

NUC-7738 Usage And Synthesis

Uses

NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer[1].

References

[1] Serpi M, et, al. Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent. J Med Chem. 2022 Dec 8;65(23):15789-15804. DOI:10.1021/acs.jmedchem.2c01348

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