Methyl tetrazine OH Chemical Properties

Melting point:

224-226 °C

Boiling point:

434.9±47.0 °C(Predicted)

Density 

1.322±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Solid

pka

7.17±0.15(Predicted)

color 

Pink to red

Methyl tetrazine OH Usage And Synthesis

Description

4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenol is a linker containing a methyltetrazine and a hydroxy moiety. This reagent enables simple and efficient incorporation of a tetrazine moiety onto antibodies, TCO-containing peptides and other TCO-attached molecules.

Uses

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Alkyl-Chain

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methyl tetrazine OH(58884-35-8)Related Product Information

• Methyltetrazine-PEG8-NHS ester
• Methyltetrazine-propylamine HCl salt
• Methyltetrazine-NHS Ester