TRPV4 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Monkey

Background

TRPV4 is a member of the transient receptor potential vanilloid family of ion channels, and functions as a Ca2+-permeant non-selective cation channel. TRPV4 channels are expressed in many cell types, with particular abundance in sensory and spinal neurons. TRPV4 channels play a role in maintaining cellular homeostasis, by facilitating transmembrane Ca2+ transport in response to various stimuli, including thermal stress, fatty acid metabolites, and hypotonicity. Mutations in the TRPV4 gene have consequently been attributed to a variety of pathological conditions. For example, constitutively active TRPV4 mutants can lead to excess Ca2+ influx, resulting in toxicity and degeneration of peripheral nerves. TRPV4-dependent Ca2+ influx was also shown to mediate strain-induced and TGFβ1-induced epithelial-mesenchymal transition, suggesting a mechanistic role for TRPV4-mediated Ca2+ transport in fibrosis and oncogenesis. Consistent with this, studies in capillary endothelial cells showed that mechanical strain-induced Ca2+ influx through TRPV4 promote focal adhesion and stress fiber remodeling, mediated specifically through integrins, PI3K, and downstream kinases including Rho and ROCK.

References

[1] Everaerts, W. et al. (2010) Prog Biophys Mol Biol 103, 2-17.
[2] Vriens, J. et al. (2004) Proc Natl Acad Sci U S A 101, 396-401.
[3] Fecto, F. et al. (2011) J Biol Chem 286, 17281-91.
[4] Sharma, S. et al. (2019) J Cell Mol Med 23, 761-74.
[5] Thodeti, C.K. et al. (2009) Circ Res 104, 1123-30.

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