1-Bromo-3,5-difluorobenzene Chemical Properties

Melting point:

-27 °C

Boiling point:

140 °C (lit.)

Density 

1.676 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.499(lit.)

Flash point:

112 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

0.238g/l

form 

Liquid

color 

Clear colorless to light yellow

Specific Gravity

1.686

PH

6.6 (0.238g/l, H2O, 20℃)

Water Solubility 

0.238 g/L (20 ºC)

BRN 

1931520

InChIKey

JHLKSIOJYMGSMB-UHFFFAOYSA-N

CAS DataBase Reference

461-96-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,N,F,Xi

Risk Statements 

10-22-38-43-48/22-50/53-36/37/38

Safety Statements 

24-36/37-60-61-36-26-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

2

Hazard Note 

Flammable

HazardClass 

3

PackingGroup 

III

HS Code 

29039990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Bromo-3,5-difluorobenzene Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

1-Bromo-3,5-difluorobenzene was used in the synthesis of 4-bromo-2,6-difluorobenzoic acid.

Uses

Intermediates of Liquid Crystals

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 486, 1987 DOI: 10.1021/jm00386a008

Synthesis

General procedure: A diazonium salt solution was prepared by dissolving 1 mole of 2-bromo-4,6-difluoroaniline hydrobromide in aqueous HCl with 1.1-1.10 moles of NaNO2 at 0°C to 5°C. The solution was then slowly warmed to 15°C, during which time the release of nitrogen was observed. To this solution, 1.5 moles of hypophosphorous acid was added at a temperature below 5°C, followed by a slow warming to 15°C, during which the release of nitrogen was observed. The reaction mixture is stirred for 1 hour, decanted and extracted with a suitable organic solvent to give 1-bromo-3,5-difluorobenzene in 75% molar yield. The target product with purity higher than 99% was obtained by distillation. This method is also applicable to the synthesis of other 1-bromo-3,5-dihalobenzenes.

References

[1] Patent: US5157169, 1992, A

1-Bromo-3,5-difluorobenzene(461-96-1)Related Product Information

• Decabromodiphenyl Ethane
• 1,3-Difluorobenzene
• 3,5-Difluorophenol
• Transfluthrin
• 1,2-Difluorobenzene
• Florfenicol
• 4-Bromofluorobenzene
• 1-Bromo-3,5-dichlorobenzene
• 1,2-Dibromotetrafluorobenzene
• 1,4-DIBROMOTETRAFLUOROBENZENE
• 2-BROMO-4,5,6-TRIFLUOROANILINE
• Bromopentafluorobenzene
• Bromine
• 1-BROMO-2,3,5,6-TETRAFLUOROBENZENE
• 1-Bromo-2,3,5-trifluorobenzene
• 2-Bromo-4,6-difluoroaniline
• 1,2-DIBROMO-3,5-DIFLUOROBENZENE
• 4,4'-DIBROMOOCTAFLUOROBIPHENYL