2-Chloro-3-pyridinamine Chemical Properties

Melting point:

76-78 °C (lit.)

Boiling point:

130-134 °C (12.7517 mmHg)

Density 

130

refractive index 

1.5110 (estimate)

Flash point:

185 °C

storage temp. 

2-8°C

solubility 

30g/l

pka

2.42±0.10(Predicted)

form 

Crystalline Powder, Crystals, and/or Chunks

color 

Off-white to yellow to pink

PH

7 (30g/l, H2O, 20℃)

Water Solubility 

Soluble in methanol and water. (30 g/L).

BRN 

109814

InChI

1S/C5H5ClN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2

InChIKey

MEQBJJUWDCYIAB-UHFFFAOYSA-N

SMILES

Nc1cccnc1Cl

CAS DataBase Reference

6298-19-7(CAS DataBase Reference)

NIST Chemistry Reference

3-Amino-2-chloropyridine(6298-19-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN2811

WGK Germany 

WGK 3

HazardClass 

IRRITANT

HS Code 

29333999

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:2-Chloro-3-pyridinamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Chloro-3-pyridinamine Usage And Synthesis

Chemical Properties

off-white to yellow to pink crystalline powder,

Uses

It is an intermediate of medicine and agricultural chemicals. It is involved in the Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds.

Synthesis

Dissolve 188g (2mol) of 3-aminopyridine in 10% hydrochloric acid: 900g (10%, 2.46mol), completely dissolved and mixed, the volume ratio of the solution to dichloromethane: 400g, sodium hypochlorite solution: 800g (10%, 1.07mol) as a preset unit time volume ratio, and then according to the unit time volume ratio at room temperature (the specific temperature range of 10 ?? -30 ?? the same below) will be pumped into the first stage extraction centrifuge for extraction centrifugation; after that, separate the organic phase and the organic phase continuously. Then, according to the unit time volume ratio at room temperature (the specific temperature range of room temperature is 10 ?? -30 ?? the same below) will be three separate and at the same time continuously pumped into the first stage of the extraction centrifuge extraction centrifugation; after that, the separation of organic phase and aqueous phase, and retain the organic phase, the aqueous phase, industrial hydrochloric acid: 59g (content of 31%, 0.5mol), dichloromethane: 200g, and sodium hypochlorite solution: 400g (10%, 0.54mol) four of the volume ratio, the content of the organic phase: 500g (content of 10 percent, 1.07mol), the volume ratio of the organic phase: 800g (content of 10 percent, 1.07mol) (content 10%, 0.54 mol) as a preset unit time volume ratio, and then in accordance with the unit time volume ratio at room temperature, the four were separately and simultaneously pumped continuously into the second stage of the extraction centrifuge extraction centrifuge; after that, the separation of organic and aqueous phases, and retaining the organic phase, and put the aqueous phase into the next stage of the extraction centrifuge; the subsequent amount of hydrochloric acid, methylene chloride, and sodium hypochlorite solution used in each stage of extraction centrifuge volume The amount of hydrochloric acid, dichloromethane and sodium hypochlorite solution used in each subsequent stage of extraction centrifuge was reduced by half, a total of five stages of continuous extraction reaction (each stage of extraction centrifugal reaction time was 3h), after which the organic phase was combined as 3-amino-2-chloropyridine solution; a total of 962g of solution was obtained, which was analyzed by liquid chromatography with external standard method, and the content of the external standard method was calculated to be 24.4%, the weight of the 3-amino-2-chloropyridine was calculated to be 234.5g, and the molar yield of 3-amino-2-chloropyridine was 91.3 The molar yield of 3-amino-2-chloropyridine was 91.3% (as 3-aminopyridine), purity was 98.4%.

2-Chloro-3-pyridinamine(6298-19-7)Related Product Information

• 2-Chloro-4-methyl-3-nitropyridine
• 3-Amino-5-bromo-2-chloropyridine
• 3-AMINO-2-CHLORO-5-PICOLINE
• 2-Chloro-3-fluoropyridine
• 2-Chloro-5-fluoronicotinonitrile
• 4-Bromo-2-chloro-3-iodopyridine
• 3-Amino-2-chloro-4-methylpyridine
• 5-Amino-2-chloro-3-picoline
• 2-CHLORO-3-FLUORO-4-IODOPYRIDINE
• 6-Bromo-2-chloro-3-iodopyridine
• 2-Chloro-3-methyl-5-nitropyridine
• 2-Chloro-3-methyl-5-bromopyridine
• 2-Chloro-3-nitro-6-methylpyridine
• 2-Chloro-5-fluoro-3-methylpyridine
• 5-Bromo-2-chloro-3-fluoropyridine
• 3-AMINO-6-BROMO-2-CHLOROPYRIDINE
• 5-Bromo-2-chloro-3-nitropyridine
• 2-Chloro-3-iodopyridine