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N,N-DIETHYLNICOTINAMIDE

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N,N-DIETHYLNICOTINAMIDE Basic information

Product Name:
N,N-DIETHYLNICOTINAMIDE
Synonyms:
  • CORVOTONE
  • DYNACORYL
  • EUCORAN
  • LABOTEST-BB LT00134638
  • PYRIDINE-3-CARBOXYLIC ACID DIETHYLAMIDE
  • PYRICARDYL
  • N,N-DIETHYLNICOTINAMIDE
  • NICKETHAMIDE
CAS:
59-26-7
MF:
C10H14N2O
MW:
178.23
EINECS:
200-418-5
Product Categories:
  • Nitrogen cyclic compounds
  • Heterocyclic Compounds
  • NIKETHYL
Mol File:
59-26-7.mol
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N,N-DIETHYLNICOTINAMIDE Chemical Properties

Melting point:
23 °C (lit.)
Boiling point:
296-300 °C (lit.)
Density 
1.06 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.524(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
pKa 3.46(H2O,t =20) (Uncertain)
form 
Liquid
color 
Clear colorless to yellow
Merck 
14,6543
BRN 
5743
InChI
InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
InChIKey
NCYVXEGFNDZQCU-UHFFFAOYSA-N
SMILES
C1=NC=CC=C1C(N(CC)CC)=O
CAS DataBase Reference
59-26-7(CAS DataBase Reference)
EPA Substance Registry System
Nikethamide (59-26-7)
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Safety Information

Hazard Codes 
T
Risk Statements 
25-36/37/38-23/24/25
Safety Statements 
26-45-36/37/39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
QS4375000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29333999
Toxicity
LD50 i.p. in rats: 272 mg/kg (Goldenthal)

MSDS

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N,N-DIETHYLNICOTINAMIDE Usage And Synthesis

Description

A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.

Chemical Properties

clear colorless to yellow liquid

Uses

analeptic

Uses

N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes.

Definition

ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

General Description

Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.

Air & Water Reactions

Water soluble.

Reactivity Profile

N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes.

Fire Hazard

N,N-DIETHYLNICOTINAMIDE is combustible.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.

References

Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971)

N,N-DIETHYLNICOTINAMIDE Preparation Products And Raw materials

Raw materials

N,N-DIETHYLNICOTINAMIDESupplier

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