N,N-DIETHYLNICOTINAMIDE Chemical Properties

Melting point:

23 °C (lit.)

Boiling point:

296-300 °C (lit.)

Density 

1.06 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.524(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

pKa 3.46(H2O,t =20) (Uncertain)

form 

Liquid

color 

Clear colorless to yellow

Merck 

14,6543

BRN 

5743

InChI

InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3

InChIKey

NCYVXEGFNDZQCU-UHFFFAOYSA-N

SMILES

C1=NC=CC=C1C(N(CC)CC)=O

CAS DataBase Reference

59-26-7(CAS DataBase Reference)

EPA Substance Registry System

Nikethamide (59-26-7)

Safety Information

Hazard Codes 

T

Risk Statements 

25-36/37/38-23/24/25

Safety Statements 

26-45-36/37/39

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

QS4375000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29333999

Toxicity

LD50 i.p. in rats: 272 mg/kg (Goldenthal)

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

N,N-DIETHYLNICOTINAMIDE Usage And Synthesis

Description

A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]_D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.

Chemical Properties

clear colorless to yellow liquid

Uses

analeptic

Uses

N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes.

Definition

ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.

Application

N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX.

General Description

Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.

Air & Water Reactions

Water soluble.

Reactivity Profile

N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes.

Fire Hazard

N,N-DIETHYLNICOTINAMIDE is combustible.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.

References

Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971)

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