15-BROMOPENTADECANOIC ACID Chemical Properties

Melting point:

66-69 °C

Boiling point:

409.4±18.0 °C(Predicted)

Density 

1.131±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

Sealed in dry,Room Temperature

pka

4.78±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

15-BROMOPENTADECANOIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 15-bromopentadecanoic acid from 15-hydroxypentadecanoic acid: 177 g (0.69 mol) of 15-hydroxypentadecanoic acid prepared in step (1) was placed in a reaction vessel and 577.4 g (3.43 mol) of 48% hydrobromic acid/acetic acid solution was added. At room temperature, 240 ml of concentrated sulfuric acid was slowly added, followed by heating and refluxing the reaction mixture for 6 hours. After completion of the reaction, it was cooled to room temperature and the organic layer was separated by extraction with dichloromethane. The organic layer was sequentially washed with water, dried over anhydrous magnesium sulfate (MgSO4) and finally concentrated under vacuum. 195 g of white 15-bromopentadecanoic acid powder was obtained in 88% yield.

References

[1] Patent: KR2017/100906, 2017, A. Location in patent: Paragraph 0124-0126
[2] Helvetica Chimica Acta, 1929, vol. 12, p. 478
[3] Synthesis, 1996, # 8, p. 1007 - 1011

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