THIODIGLYCOLIC ACID Chemical Properties

Melting point:

128-131 °C(lit.)

Boiling point:

395.6±27.0 °C(Predicted)

Density 

1,19 g/cm³

storage temp. 

-20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

pK1:3.32;pK2:4.29 (25°C)

color 

White to Off-White

Water Solubility 

very faint turbidity

Cosmetics Ingredients Functions

REDUCING

InChI

InChI=1S/C4H6O4S2/c5-3(6)1-9-10-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChIKey

DLLMHEDYJQACRM-UHFFFAOYSA-N

SMILES

S(CC(O)=O)SCC(O)=O

LogP

1.390 (est)

CAS DataBase Reference

505-73-7(CAS DataBase Reference)

EPA Substance Registry System

Acetic acid, 2,2'-dithiobis- (505-73-7)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-36/37/38

Safety Statements 

26-36/37/39-45-36

RIDADR 

UN 3261 8/PG 2

WGK Germany 

2

RTECS 

AJ6475000

F 

13

TSCA 

TSCA listed

HS Code 

2930.90.4950

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

THIODIGLYCOLIC ACID Usage And Synthesis

Uses

Thiodiglycolic acid is a major metabolite of vinyl chloride monomer and ifosfamide (an anti-cancer drug) in human urine. It is used as an analytical reagent for the detection of copper, lead, mercury and silver.

Definition

ChEBI: Thiodiacetic acid is a dicarboxylic acid.

Synthesis

Dithiol dihydroxyacetic acid was prepared as follows: 120g of 2-mercaptoacetic acid, 500g of ethyl acetate and 0.6g of potassium iodide were mixed homogeneously under the condition of temperature of 20??C according to mass to form solution A; 80g of hydrogen peroxide with the concentration of 30wt% was added to solution A slowly and the reaction was kept in a warm state for 2h; at the end of the reaction, the obtained solution was washed by 300mL of saturated sodium sulfite solution. After washing and evaporating ethyl acetate under reduced pressure, dithiol dihydroxyacetic acid was obtained.

THIODIGLYCOLIC ACID(505-73-7)Related Product Information

• Phenyl isothiocyanate
• 4-tert-Butyltoluene
• 4'-tert-Butylacetophenone
• 1,2-Ethanedithiol
• ChroMiuM hydroxide
• Glyoxylic acid
• BARIUM THIOSULFATE
• Thiodiglycolic acid
• Glycolic acid
• Dimethyl sulfide
• Diglycolic acid
• THIODIGLYCOLIC ACID
• DIAMMONIUM 2,2'-DITHIODIACETATE
• 2,2'-DITHIODIPROPIONIC ACID
• BIS(2-ETHYLHEXYL) DITHIODIACETATE
• 2,2'-DITHIODIACETIC ACID AMMONIUM SALT
• DIBUTYL DITHIODIGLYCOLLATE
• AURORA KA-8099