2,4-Dichloropyrido[2,3-d]pyrimidine Chemical Properties

Melting point:

157-158 °C (decomp)

Density 

1.573±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-0.38±0.30(Predicted)

2,4-Dichloropyrido[2,3-d]pyrimidine Usage And Synthesis

Reactivity Profile

Selective disubstitution of 2,4-dichloropyrido[2,3-d]pyrimidine with various nucleophiles was investigated by Lavecchia et al. Suzuki and Stille cross-coupling reactions on monosubstituted compound 4-tert-butylamino-2-chloro-pyrido[2,3-d]pyrimidine were performed in high yields. ,4-dichloropyrido[2,3-d]pyrimidine was easily substituted at position 4 with different nucleophiles. This position was more reactive than position 2, as in simple pyrimidinic systems. 2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method.

Synthesis

2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method[1].

References

[1] G. Lavecchia, G. Guillaumet, S. Berteina-Raboin. “Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions.” Tetrahedron Letters 46 35 (2005): Pages 5851-5855.

2,4-Dichloropyrido[2,3-d]pyrimidine(126728-20-9)Related Product Information

• 2,4-dichloropyrido[3,2-d]pyrimidine
• 2,4-dichloropyrido[3,4-d]pyrimidine
• 4,6-DICHLOROPYRIDO[3,4-D]PYRIMIDINE
• 4,7-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
• 2,4-DICHLORO-7-METHYLPYRIDO[2,3-D]PYRIMIDINE
• 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
• 4-CHLOROPYRIDO[2,3-D]PYRIMIDINE