N-(4,6,7-TRIMETHYLQUINAZOLIN-2-YL)GUANIDINE Chemical Properties

Melting point:

259-260 °C (decomp)

Boiling point:

435.9±55.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

Methanol : 5 mg/mL (21.81 mM; ultrasonic and warming and heat to 60°C)|DMSO : 2 mg/mL (8.72 mM; ultrasonic and warming and heat to 60°C)

pka

8.13±0.30(Predicted)

form 

Solid

color 

White to off-white

N-(4,6,7-TRIMETHYLQUINAZOLIN-2-YL)GUANIDINE Usage And Synthesis

Definition

ChEBI: 2-(4,6,7-Trimethyl-2-quinazolinyl)guanidine is a member of quinazolines.

Biological Activity

A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively[1].

References

[1]. Thomas R Webb, et al. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. Bioorg Med Chem. 2003 Jan 2;11(1):77-85.

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